Anti-arrhythmic drugs are a mainstay in the management of symptoms related to arrhythmias, and are adjuncts in prevention and treatment of life-threatening ventricular arrhythmias. However, they also have the potential for pro-arrhythmia and thus the prediction of arrhythmia predisposition and drug response are critical issues. Clinical trials are the latter stages in the safety testing and eff...

conclusions safety motivation and work pressure are important predictors of occupational accident rate. therefore, increasing safety motivation and reducing work pressure in high-risk jobs are effective ways in which organizations can decrease occupational accident rates. results both safety motivation and work pressure were significantly correlated with occupational accident rate (p < 0.0001)....

System safety research has a weakness in terms of evaluation. In particular, the field has a poor track record for applying appropriate research methods to the questions we wish to answer, and for evaluating the answers in a convincing way. Given changes in government and public attitudes to research funding, this will be an increasing concern in the near future. In this paper, we define a taxo...

The pursuit of patient safety involves reducing the gap between best practice and the care actually delivered to patients. Understanding how to reliably deliver best practice care using established anaesthetic techniques may, today, be more important than seeking new ones. Advances in anaesthesia safety involve analysing failures and devising strategies to address these. However, anaesthetists ...

Safety cases are now regularly used to communicate the argument about the achievement of acceptable levels of safety for safety critical systems. Increasingly, safety standards such as Defence Standard 00-56 require the scope of the safety case to cover not only the development of the system, but also operating and maintenance through life, including decommissioning. This involves two dimension...

In previous papers, we asserted that software system safety is primarily concerned with epistemic questions, that is, questions concerning knowledge and the degree of confidence that can be placed in that knowledge. We also enumerated a set of 21 foundational epistemic questions, discussed some of the difficulties that exist in answering these questions adequately today, and speculated briefly ...

Despite the rapidly expanding armamentarium of analgesic drugs and techniques for the management of perioperative pain, effective prevention of acute postsurgical pain still poses unique challenges for practitioners 1. An increasing number of complex operations are being performed on an outpatient basis for which the use of conventional opioid-based IV patient-controlled analgesia (PCA) and cen...