T he pursuit of investigations into the science of aging is really designed to understand why cellular processes begin to fail with advancing age, and what molecular events contribute to this failure. In this regard, the distinction between aging and the diseases associated with aging becomes less clear, and they are most likely driven by the same or similar events related to biological decline...

Classical Hodgkin lymphoma (HL) is a unique type of and its pathobiology has long remained enigmatic. Several key features HL account for this. First, the Reed-Sternberg (HRS) tumor cells usually represent less than few percent among complex immunological microenvironment. Second, HRS originate from mature B cells, likely pre-apoptotic germinal center (GC) but have lost most B-cell typical gene...