A library of aromatic/heterocyclic sulfonamides possessing a large diversity of scaffolds has been assayed for inhibition of the carbonic anhydrase (CA, EC 4.2.1.1) from the malaria parasite Plasmodium falciparum (pfCA). Low micromolar and submicromolar in vitro inhibitors were detected, whereas several compounds showed ex vivo anti-P. falciparum activity, in cell cultures. One derivative, that...

OBJECTIVE The aim of this study was to compare muscle activation patterns and patellofemoral joint morphologies between patients with knee osteoarthritis with and without patellar malalignment. SUBJECTS The subjects were divided into 3 groups. Group A comprised 11 patients with symptomatic knee osteoarthritis without patellar malalignment. Group B comprised 14 patients with symptomatic knee o...

background: chondromalacia patella is the most common cause of mechanical knee pain in young women. q angle and knee alignment are important clinical parameters for biomechanics of the patellofemoral joint. objective: to identify the prevalence of knee malalignment and to find out if there is a correlation between knee mal alignment and q angle with age at onset of disease. methods: all patient...

Background: Patellofemoral anatomy has not been well characterized. Applying deep learning to automatically measure knee can provide a better understanding of anatomy, which be key factor in improving outcomes. Methods: 483 total patients with CT imaging (April 2017–May 2022) from 6 centers were selected cohort scheduled for arthroplasty and healthy anatomy. A 7 patellofemoral landmarks annotat...

The patello-femoral joint (PFJ) enhances our ability of knee flexion and extension and is assumed to have evolved through men's ability of having adopted a bipedal gait. This articulation between patella and femur is relatively complex and displays intricate biomechanical behaviour. Forces in the patello-femoral joint are a function of the quadriceps force, and the angle of flexion of the knee....

INTRODUCTION Patients with patellofemoral instability with trochlear dysplasia may be treated with trochlear osteotomy. CASE PRESENTATION We present a patient with patellofemoral instability treated with trochlear osteotomy. The procedure resulted in nonunion with painful bony impingement and isolated patellofemoral osteoarthritis. Patellofemoral arthroplasty was performed. CONCLUSION Patel...

Minor degrees of malalignment of the patella and anatomical abnormalities including a flattened sulcus angle and an increased ratio between patellar tendon length and patellar length (PT:P) have been suggested as predisposing factors in the causation of chondromalacia patellae, as well as patellar instability. In order to confirm or refute this hypothesis a prospective study has been performed ...

Knee alignment measurements are one of the most extended indicators of knee-complex injuries such as anterior cruciate ligament injury and patellofemoral pain syndrome. The Frontal Plane Projection Angle (FPPA) is widely used as a 2-D estimation of knee alignment. However, traditional procedures to measure this angle suffer from practical limitations, which leads to huge time investments when e...

UNLABELLED Fundamental to rational, safe, and effective treatment for any orthopaedic condition is an accurate understanding of the etiology of the symptoms. The decades-old paradigm of a pure structural and biomechanical explanation for the genesis of patellofemoral pain is giving way to one in which biologic factors are being given more consideration. It is increasingly evident that a variabl...

First, we introduce the concept of intuitionistic fuzzy group congruenceand we obtain the characterizations of intuitionistic fuzzy group congruenceson an inverse semigroup and a T^{*}-pure semigroup, respectively. Also,we study some properties of intuitionistic fuzzy group congruence. Next, weintroduce the notion of intuitionistic fuzzy semilattice congruence and we givethe characterization of...