Introduction: The role of serotonergic fibers in avoidance learning is controversial. Involvement of the dorsal raphe nucleus (DRN), the main source of hippocampal projecting serotonergic fibers in acquisition, consolidation and retrieval of passive avoidance (PA) learning, was investigated by functional suppression of this area. Materials and Methods: DRN functional inactivation was done by li...

Introduction: Previous studies have shown that sesame oil affects memory and learning. In the present work, effect of a diet containing 10% sesame oil used during pregnancy was evaluated on short-term passive avoidance learning of offspring rats by Shuttle box. Methods: Female Wistar rats were divided into 2 groups (n = 9 each group). Control group consumed regular diet during pregnancy and...

Background and Objective: Chlorogenic acid (CGA) is a major polyphenolic component of coffee. Reduction in the risk of a variety of diseases following CGA consumption has been mentioned in recent studies. The effect of CGA on learning and memory in rats with cognitive deficit induced by intracerebroventricular streptozotocin (STZ) and  acetylchoinesterase (AChE) activity was evaluated in this s...

There are several conflicting evidences showing the effect of morphine on learning and memory processes. In the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using Passive Avoidance shuttle box and Morris Water Maze tasks were investigated, respectively. Male rats received morphi...

In this study we tested the hypothesis that nitric oxide (NO), which function as a novel type of inter-cellular messenger in the central nervous system (CNS) participated in the facilitator effect of arginine vasopressin (AVP) on learning and memory. Recent investigations have provided evidences that inhibition of NO synthesis attenuated the vasodilatation caused by AVP, and inhibited the impro...

objective: estrogen deficit following menopause results in cognitive behaviors impairment. severity of these impairments in menopause women suffer with cerebral hypo perfusion/ischemia (hi) cause the brain damage and neuronal death. this study aimed to evaluate the effects of pomegranate seed extract (pgse) on avoidance memories after permanent bilateral common carotid arteries occlusion (2ccao...

The present study examined the influence of dexefaroxan, a potent and selective alpha(2)-adrenoceptor antagonist, on cognitive performance in rodents. In young adult rats, dexefaroxan reversed the deficits induced by UK 14304 [5-bromo-N-(4,5-dihydro-1-H-imidazol-2-yl)-6-quinoxalinamine], scopolamine, and diazepam in a passive avoidance task. In this test, dexefaroxan also attenuated the spontan...

There are several conflicting evidences showing the effect of morphine on learning and memory processes. In the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using Passive Avoidance shuttle box and Morris Water Maze tasks were investigated, respectively. Male rats received morphi...

introduction: drugs of abuse such as nicotine and morphine used systemically by addicts produce their effects via the mesolimbic dopaminergic pathway. furthermore, evidence indicates that some behavioral effects of nicotine and morphine are mediated by nitric oxide (no). based on these observations, the aim of the present study was to investigate the effects of intra-nucleus accumbens (nac) inj...