In a series of 24-hour ambulatory EEG recordings from 1,000 consecutive adult outpatients (44.5% with generalized and 55.5% with partial epilepsy, one recording per patient), the authors found only 46 (4.6%) activations of epileptiform discharges on awakening. All recordings came from patients with idiopathic generalized epilepsy, predominantly with juvenile myoclonic epilepsy and generalized t...

Epilepsy is a neurological disease arising from abnormal and uncontrollable electrical firings of a group of neurons appearing in the central nervous system. Experimental epilepsy models have been developed to assess the pathophysiology of epileptic seizures and to search for new effective anti-epileptic drugs. This chapter is designed to describe characteristics of experimental epilepsy models...

− Malformations of the cerebral cortex (MCC) are often associated with severe epilepsy and developmental delay. About 40% of drug-resistant epilepsies are caused by MCC. Classification of MCC is based on embryological brain development, recognising forms that result from faulty neuronal proliferation, neuronal migration and cortical organisation. Hemimegalencephaly, an enlarged dysplastic hemis...

In a previous study we reported difficulty with expressive language and visuoperceptual ability in preschool children with epilepsy and otherwise normal development. The present study analysed speech and language dysfunction for each individual in relation to epilepsy variables, ear preference, and intelligence in these children and described their auditory function. Twenty 6-year-old children ...

PURPOSE To assess the prevalence of epilepsy in a rural district of Lao PDR and to describe the clinical and epidemiological profile of the disease. METHODS Door-to-door screening was performed on the entire population of 8 randomly selected villages in the Hinheub district, using an internationally validated and standardized questionnaire. Additional passive case detection was performed thro...

To assess the impact of the duration of epilepsy, the clusters of seizures and/or epileptic status, the type of epilepsy and seizures, and the mono-/ polytherapy on the quality of life (QOL) of Bulgarian patients with refractory epilepsy (RE). Seventy patients with RE were studied using a purposeful interview on the patients’ disease course, as well as an exam of the patients’ medical documenta...