Overall salivary gland tumours are rare, comprising of less than 3% of overall head and neck neoplasms. Parotid gland is the most common site for the benign salivary gland neoplasm. Usually they are painless slow growing lesion involving the superficial or deep part of the gland and can severely affect the facial nerve functioning. Treatment mainly comprises of surgical excision with preservati...

The major salivary glands consist of the parotid, the submandibular, and the sublingual glands. Under the control of the parasympathetic nervous system, the major salivary glands are responsible for the principal portion of saliva produced, which can be as much as 1.5 liters per day. The minor salivary glands of the oral cavity, pharynx, and upper airways contribute only a small percentage of t...

Previous reports suggested that there is no significant difference in the binding affinity of pilocarpine and cevimeline on muscarinic receptors (1). However, in vivo studies from our laboratory suggested that pilocarpine-induced salivation from the parotid gland is greater than that induced by cevimeline in rats. Therefore, in the present study, sialogogue-induced intracellular Ca(2+) mobiliza...

BACKGROUND/AIM Human papillomavirus (HPV) is implicated in head and neck squamous cell carcinomas. However, the causal role of HPV in carcinomas of the parotid gland remains uncertain and less documented. This study aimed to determine the potential implication of HPV in the development of benign and malignant lesions of the parotid gland. MATERIALS AND METHODS Paraffin-embedded biopsies were ...

  Extra-skeletal Ewing’s sarcoma is a rare soft tissue malignant neoplasm, morphologically indistinguishable from skeletal Ewing’s sarcoma. The usual sites of involvement are the soft tissues of para-vertebral region, chest wall, and lower extremity. Extra-skeletal Ewing’s sarcoma is rare in the head and neck region and very few cases are reported in the parotid gland. The cytological features...

The murine parotid secretory protein (PSP) gene is expressed selectively at high levels in parotid and sublingual salivary glands. Previously, the transcriptional activity of a PSP mini-gene, called Lama, was shown to be dependent on a 1.5 kb region located 3 kb upstream of the transcription start site. Here, functional studies in transgenic mice demonstrate that this proximal regulatory region...

Canalicular adenoma is a rare benign salivary gland neoplasm affecting predominantly the minor gland. We present case of 55 year female who presented with mucosal nodule in left cheek and was diagnosed as based on morphology immunohistochemistry findings. Our that, it major – Parotid gland, 7 reported literature to best our knowledge.

INTRODUCTION Tuberculosis of the parotid gland is a rare clinical entity which causes some difficulties in diagnosis because of the similarities in presentation to that of a neoplasm. Diagnosis mainly relies in the treating physician having a high index of suspicion. The diagnosis is generally overlooked by otolaryngologists and most cases are undergoing unnecessary surgery. CASE PRESENTATION...