The effect of sodium valproate 1200 mg daily on the disability of Parkinsonism and on levodopa-induced dyskinesia was assessed in a double-blind crossover trial with matched placebo in 12 patients with Parkinson's disease. No objective change in the severity of Parkinsonism or dyskinesias was noted. However, six out of nine patients who completed the trial noted a slight to moderate improvement...

objective(s): parkinson's disease (pd) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. evidence indicates that pd occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. it is reported that soy genistein, an estrogen agonist phytoestrogen, display neuro...

Since 1947 a number of chemists who used MPTP for legitimate purposes developed Parkinsonism. Final recognition that MPTP induces Parkinsonism came in 1982 when a batch of an illicit narcotic (MPPP) became contaminated to form MPTP and a group of users demonstrated profoundly disabling Parkinsonism. Parkinson’s is a progressive neurological condition, which is characterised by both motor (movem...

Parkinsonism and portosystemic encephalopathy (PSE) are cerebral disorders associated with motor and neuropsychological dysfunctions that may occur in patients with chronic liver disease. We describe a patient with parkinsonism and neuroradiologic and 1H spectroscopic findings of PSE associated with a large congenital intrahepatic portosystemic venous shunt. Chronic liver disease was absent. Af...

The young age of the patient, appearance of his symptoms after a stroke, spontaneous improvement unrelated to treatment, lucencies seen on CT within the basal ganglia, and a relatively high level of HVA in cerebrospinal fluid, higher than usually seen in idiopathic Parkinson's disease,9 are in favour of this diagnosis. Other causes of Parkinsonism, such as normal pressure hydrocephalus or neuro...

There is now growing evidence that parkinsonism and other extrapyramidal signs are highly prevalent in patients with first-episode psychosis who have never been exposed to antipsychotic drugs. However, the neurocognitive correlates of parkinsonism in this population remained to be clarified. A sample comprising 100 consecutive drug-naive patients with first-episode psychosis were enrolled on th...

Neuropeptide Y is a novel bioactive substance that plays a role in the modulation of neurogenesis and neurotransmitter release, and thereby exerts a protective influence against neurodegeneration. Using a sensitive immunohistochemical method with a tyramide signal amplification protocol, we performed a post-mortem analysis to determine the striatal localization profile of neuropeptide Y in neur...

INTRODUCTION Parkinsonism puts a high direct cost burden on both patient and caregiver. Several reports of drug-induced parkinsonism have been published, but to the best of our knowledge, there has not been any report of quinine or halothane inducing parkinsonism. CASE PRESENTATION We describe two cases of parkinsonism possibly caused by adverse drug reaction to quinine in a 29-year-old black...

BACKGROUND Few studies have compared cognitive functions in multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and Parkinson's disease (PD). AIM To compare the results of cognitive function tests in the three diseases and examine their relation with the severity of parkinsonism. SETTINGS AND DESIGN Clinic-based open prospective study. MATERIALS AND METHODS Global cognitiv...

Main Outcome Measures: This multicenter casecontrol study compared lifelong occupational and job task histories to determine associations with parkinsonism and certain clinical subtypes (postural instability and gait difficulty and age at diagnosis 50 years). Results: Findings in 519 cases and 511 controls were analyzed. Work in agriculture, education, health care, or welding was not associated...