Humans generate bipedal walking by cooperatively manipulating their complicated and redundant musculoskeletal systems to produce adaptive behaviors in diverse environments. To elucidate the mechanisms that generate adaptive human bipedal locomotion, we conduct numerical simulations based on a musculoskeletal model and a locomotor controller constructed from anatomical and physiological findings...

World-class utilization of manufacturing resources is of vital importance to any manufacturing enterprise in the global competition of today. This requirement calls for superior performance of all processes related to the manufacturing of products. One of these processes is the resetting of machinery and equipment between two product runs, which will be the focus area of this text. This paper e...

Findings in animal models demonstrate that activity within hierarchically early sensory cortical regions can be modulated by cross-sensory inputs through resetting of the phase of ongoing intrinsic neural oscillations. Here, subdural recordings evaluated whether phase resetting by auditory inputs would impact multisensory integration processes in human visual cortex. Results clearly showed audi...

Phase resetting curves characterize the way a system with a collective periodic behavior responds to perturbations. We consider globally coupled ensembles of Sakaguchi-Kuramoto oscillators, and use the Ott-Antonsen theory of ensemble evolution to derive the analytical phase resetting equations. We show the final phase reset value to be composed of two parts: an immediate phase reset directly ca...

Disruption of redox homeostasis is a crucial factor in the development of drug resistance, which is a major problem facing current cancer treatment. Compared with normal cells, tumor cells generally exhibit higher levels of reactive oxygen species (ROS), which can promote tumor progression and development. Upon drug treatment, some tumor cells can undergo a process of 'Redox Resetting' to acqui...

The rodent naive pluripotent state is believed to represent the preimplantation inner cell mass state of the developing blastocyst and can derive self-renewing pluripotent embryonic stem cells (ESCs) in vitro. Nevertheless, human ESCs exhibit epigenetic, metabolic, and transcriptomic characteristics more akin to primed pluripotent stem cells (PSCs) derived from the postimplantation epiblast. Un...

Resetting of epigenetic marks, such as DNA methylation, in germ cells or early embryos is not always complete. Epigenetic states may therefore persist, decay or accumulate across generations. In spite of mounting empirical evidence for incomplete resetting, it is currently poorly understood whether it simply reflects stochastic noise or plays an adaptive role in phenotype determination. Here, w...

The pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) differentially attenuates Akt, PKC, and ERK1/2 signaling, thereby controlling the duration and amplitude of responses evoked by these kinases. PHLPP1 is expressed in the mammalian central clock, the suprachiasmatic nucleus, where it oscillates in a circadian fashion. To explore the role of PHLPP1 in vivo, we have ...

Recordings of the membrane potential from a bursting neuron were used to reconstruct the phase curve for that neuron for a limited set of perturbations. These perturbations were inhibitory synaptic conductance pulses able to shift the membrane potential below the most hyperpolarized level attained in the free running mode. The extraction of the phase resetting curve from such a one-dimensional ...