Abstract In the era of deep learning, modeling for most natural language processing (NLP) tasks has converged into several mainstream paradigms. For example, we usually adopt sequence labeling paradigm to solve a bundle such as POS-tagging, named entity recognition (NER), and chunking, classification like sentiment analysis. With rapid progress pre-trained models, recent years have witnessed ri...

H. Spallek; J. O’Donnell;, M. Clayton; P. Anderson; A. Krueger School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA USA; Department of Restorative Dentistry and Comprehensive Care School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA USA; Center for Dental Informatics School of Dental Medicine, University of Pittsburgh, Pittsburgh PA USA; Emerging Technologies Libra...

Bortezomib (Velcade, formerly PS-341) is a peptide boronate inhibitor of the proteasome that was developed for cancer therapy by Julian Adams, Peter Elliott, and their colleagues.1 At the time, this was considered a very bold move, since loss of proteasome function was thought to be incompatible with viability in normal cells. However, using a novel assay that directly measures 20S proteasome a...