background: cervical cancer is the most prevalent tumor in developing countries and the second most frequent cancer among female population worldwide. specific human papillomaviruses and, most notably, hpv types 16 and 18 are recognized as being caus-ally associated with cervical carcinomas. the early hpv type 16 genes, e6 and e7, di-rectly participate in the in vitro transformation of primary ...

The role of viral structural proteins in the initiation of adaptive immune responses is poorly understood. To address this issue, we focused on the effect of noninfectious papillomavirus-like particles (VLPs) on dendritic cell (DC) activation. We found that murine bone marrow-derived dendritic cells (BMDCs) effectively bound and rapidly internalized bovine papillomavirus VLPS: Exposure to fully...

Human Papillomaviruses are viruses that infect the epithelial layers of the oral, rectal, vaginal, and cervical mucosa. There is a causal link between the development of cervical cancer and some other cancers and high-risk human papillomavirus infection (1, 2). Currently there is no prophylactic or therapeutic vaccine available against human papillomavirus infection and its associated lesions. ...

OBJECTIVE To assess the effect of introducing testing for human papillomavirus combined with liquid based cytology in women with low grade cytological abnormalities. DESIGN Observational before and after study. SETTING Three cervical screening laboratories, England. PARTICIPANTS 5654 women aged 20-64 with low grade cytological abnormalities found at routine cervical screening in a pilot; ...

Background There are 2 known pathways for tumorigenesis of vulvar squamous cell carcinoma—a human papillomavirus–dependent pathway characterized by p16 overexpression and a papillomavirus–independent linked to lichen sclerosus, TP53 mutation. A correlation papillomavirus dependency with favorable prognosis has been proposed. Objective The objective the study was further understand role p53 stat...

We report here the complete genome sequence of the first papillomavirus detected in a New World primate, howler monkey, Alouatta guariba clamitans papillomavirus 1 (AgPV1), from the Atlantic Forest in São Paulo State, Brazil.

BACKGROUND In China, various assays for human papillomavirus (HPV) genotyping are currently used for cervical cancer screening. However, a proficiency test system is not available for standardizing and evaluating assay performance. The aim of this study was to evaluate the performance of clinical laboratories for their ability to discriminate 9 HPV types with the proficiency panel. METHODS Th...

In this study, cottontail rabbit papillomavirus infection of domestic rabbits was used as an animal model to develop papillomavirus early gene-based vaccines. Groups of rabbits were intracutaneously vaccinated with single papillomavirus early genes E1, E2, E6, and E7 or with a combination of these four genes. Only a fraction of rabbits were protected from subsequent viral challenge when vaccina...

AIMS To assess the role of human papillomavirus in the pathogenesis of adenocarcinoma in situ, endocervical glandular dysplasia (a presumed precursor of adenocarcinoma) and endocervical glandular epithelial giant cell change. METHODS Viral detection was carried out using an in situ hybridisation technique on paraffin wax sections. Biotinylated probes for human papillomavirus types 6/11, 16/18...

Abstract Objective This study aimed to clarify the association between both hypoxia-inducible factor-1α and glucose transporter type-1 expression survival outcome in advanced pharyngeal cancer without human papillomavirus infection. Method Twenty-five oropharyngeal 55 hypopharyngeal patients infection were enrolled. All had stage III–IV lesions underwent concurrent chemoradiotherapy or surgery....