The Japanese randomized trial comparing standard D2 with D2 plus additional para-aortic lymph node (PAN) dissection for advanced gastric cancer (JCOG study 9501) did not demonstrate any difference in survival between the two groups. It is unknown whether there is any prognostic benefit in dissection for subgroups of PAN. Non-inferiority in survival of the patients with PAN metastasis to the pat...

BACKGROUND Fairy shrimps (Anostraca), tadpole shrimps (Notostraca), clam shrimps (Spinicaudata), algae (primarily filamentous blue-green algae [cyanobacteria]), and suspended organic particulates are dominant food web components of the seasonally inundated pans and playas of the western Mojave Desert in California. We examined the extent to which these branchiopods controlled algal abundance an...

We report the complete genome assembly of the Streptococcus pyogenes type emm4 strain MEW427 (also referred to as strain UM001 in the Pediatric Acute-Onset Neuropsychiatric Syndrome [PANS] Research Consortium), a throat isolate from a child with acute-onset neuropsychiatric symptoms meeting clinical criteria for PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococc...

High-order methods and hybrid turbulence models have independently shown promise as means of decreasing the computational cost scale-resolving simulations. The objective this work is to develop combination these analyze effects high-order discretizations on models, particularly with respect optimal model parameters relative accuracy benefits compared approaches such under-resolved direct numeri...

BACKGROUND Only a few studies to evaluate groundwater fluoride in Eastern Africa have been undertaken outside the volcanic belt of the Great Eastern Africa Rift Valley. The extent and impact of water fluoride outside these regions therefore remain unclear. The current study evaluated fluoride levels in household water sources in Bondo-Rarieda Area in the Kenyan part of the Lake Victoria Basin (...

The plain east of the Neusiedler See, the “Seewinkel” (Fig. 1), is one of the most important biodiversity hot-spot regions in Austria. A number of factors contribute to its richness: (1) The area is situated geographically within the Hungarian plain, i.e. open towards the east but isolated from the west by several mountain ridges. Thus, many organisms with a Central Asian or ancient Mediterrane...

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are a subtype of acute-onset obsessive-compulsive disorder (OCD) thought to be caused by an autoimmune response to group A streptococcal infection. Based on this proposed pathophysiology, alternative treatments for acute-onset OCD have been introduced, including antibiotics and immunomodulatory int...

Abstract Background Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS/PANS) are defined by abrupt onset and episodic course of symptoms infection. There challenges in the application published diagnostic criteria, frequency diagnosis is unknown. To date, there little data on clinical practice patterns diagnosis, assessment treatment. Objectives The...

The primary objective of pelleting is to produce a palatable, high quality product with minimum production expense. Manipulation of the feed pellets during the storage, transporting, and transfer to feeding lots seriously reduces the number of feed pellets that finally reach the feed pans. It seems that the best solution for this problem is to increase the Pellet Durability Index (PDI) of the f...