Poly(amidoamine) (PAMAM) dendrimers of different generations with carboxyl, acetyl, and hydroxyl terminal groups and a folic acid (FA)-dendrimer conjugate were separated and analyzed using reverse-phase high performance liquid chromatography (HPLC). Analysis of both the individual PAMAM derivatives and the separation of mixed generations can be achieved using a linear gradient 0-50% acetonitril...

We report construction of monodisperse PAMAM-type dendrimers based on a dodecahydroxy closo-dodecaborane scaffold. The ideal sphericity and high functional group density of the icosahedral core permits ready access to hybrid dendrimers (dendritic closomers) having rigid, uniformly shaped exterior surfaces.

Dendrimers have a highly branched nanoscale architecture with low polydispersity and high functionality. Therefore, dendrimers been widely used for nanocarriers in drug delivery systems. This paper gives an overview of the recent progress on the evaluation of pharmacokinetic and pharmacodynamic (PK/PD) profiles of PAMAM dendrimers based Simvastatin (SMV) oral formulation in rats. The mechanism ...

Weakly charged solid substrates can be nano-patterned in liquid-like order with large and well-defined spacing by adsorbing poly(amido amine) (PAMAM) dendrimers; highly charged substrates lead to lower spacing due to electrostatic three-body attractions between the dendrimers and the substrate.

Molecular encapsulation of anionic porphyrins in NH2-terminated polyamidoamine (PAMAM) dendrimers and the interfacial behavior of the dendrimer-porphyrin associates were studied at the polarized water|1,2-dichloroethane (DCE) interface. Formation of the ion associates was significantly dependent on the pH condition and on generation of dendrimers. 5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrin...

Abstract PAMAM dendrimers modified silica gel terminated phenylphosphonic acid-amide moieties (Si-6G PAMAM-PPAAM) was prepared for uranium(VI) adsorption from aqueous solutions by batch and fixed-bed column methods. The experimental results showed that the maximum capacity 434.78 mg g −1 . Equilibrium isotherm data obeyed Langmuir model. Kinetic followed pseudo-second order model thermodynamic ...

Dendrimers are well-defined nanoparticles, which have far-reaching application in the field of chemistry. Many efforts been devoted to development dendrimer due thier unique structure and various properties broad application. It helps varieties purposes as a catalyst drug delivery design. The topological descriptor analyze structure–property relationship chemical compounds. In this paper, some ...

Ovarian cancer is the most lethal gynecological malignancy. Current treatment modalities include a combination of surgery and chemotherapy, which often lead to loss of fertility in premenopausal women and a myriad of systemic side effects. To address these issues, we have designed poly(amidoamine) (PAMAM) dendrimers to selectively target the follicle stimulating hormone receptor (FSHR), which i...

The development of efficient and biocompatible non-viral vectors for gene therapy remains a great challenge, and exploiting the properties of both nanoparticle carriers and cationic polymers is an attractive approach. In this work, we have developed gold nanoparticle (AuNP) polyamidoamine (PAMAM) conjugates for use as non-viral transfection agents. AuPAMAM conjugates were prepared by crosslinki...

Amphiphilic dendrimer-based gene delivery vectors bearing peripheral alkyl sulfonyl hydrophobic tails were constructed using low-generation PAMAM-G2 as the core and functionalized by means of the aza-Michael type addition of its primary amino groups to vinylsulfone derivatives as an efficient tool for surface engineering. While the unmodified PAMAM-G2 was unable to efficiently transfect eukaryo...