BACKGROUND Scorpion sting is a public health problem in Khuzestan, South-West Iran. The aims of the current study were to monitor the hospitalized children, due to scorpion sting, and releasing more clinical and epidemiologic data related to scorpionism in this Province. METHODS In this retrospective study, the data of scorpion sting victims, among the hospitalized children in Abuzar Children...

background: scorpion sting is a public health problem in khuzestan, south-west iran. the aims of the current study were to monitor the hospitalized children, due to scorpion sting, and releasing more clinical and epidemiologic data related to scorpionism in this province. methods: in this retrospective study, the data of scorpion sting victims, among the hospitalized children in abuzar children...

Stimulator of interferon genes (STING) functions in the cytosolic DNA-sensing pathway innate immunity mammals. It is activated upon binding cyclic dinucleotide 2?3?-cGAMP, a second messenger produced by enzyme guanosine monophosphate–adenosine monophosphate synthase (cGAS), which acts as receptor for DNA this pathway, and triggers expression interferons other viral stress-induced genes. The anc...

The innate immune response is the first defence system against pathogenic microorganisms, and cytosolic detection of pathogen-derived DNA is believed to be one of the major mechanisms of interferon production. Recently, the mammalian ER membrane protein STING (stimulator of IFN genes; also known as MITA, ERIS, MPYS and TMEM173) has been found to be the master regulator linking the detection of ...

e majority of scorpion stings are generally seen with a set of simple clinical ndings, such as pain, oedema, numbness, and tenderness in the area of the sting. However, occasionally events, such as toxic myocarditis, acute heart failure, acute pulmonary oedema, and Acute Respiratory Distress Syndrome (ARDS), which occur in scorpion sting cases are a signi cant problem which determine mortality ...

Flavivirus-mediated inflammation causes neuronal death, but whether the infected neurons can evoke an innate immune response to elicit their own protection, is unknown. In an earlier study we have shown that neuronal RIG-I, play a significant role in inducing production and release of molecules that are related to inflammation. In this study, using a neuronal cell line, we show that RIG-I acts ...

Scorpion envenomation is a public health problem in tropical and subtropical countries. The majority of scorpion sting cases present with local pain at the site of sting and follow a benign clinical course. Severe intoxication may include cardiac and respiratory dysfunc-tion, leading to multi-system organ failure and death (1, 2). The deaths in scorpion sting envenomation (SE) are attributed to...

Type I interferon (IFN) production by innate immune cells is critical to prime spontaneous T cell responses against solid tumors. Emerging pre-clinical data suggests that tumor-derived DNA induces potent IFN-b production by activating a cytosolic DNA sensing receptor called STING (Stimulator of Interferon Genes), ultimately resulting in tumor antigen-specific T cell priming and in some cases, t...

We previously have reported that innate immune sensing of tumors in vivo involves type I IFN production by dendritic cells (DCs), which in turn acts on CD8a+ DCs to promote endogenous cross-priming of CD8+ T cells in vivo. Recently, we have identified the cytosolic DNA sensing pathway involving the molecule STING as the major upstream mechanism that leads to type I IFN production and DC activat...