Intravenous dexamethasone and diclofenac were evaluated in a double blind randomised trial, relative to an opioid (pentazocine) and placebo (saline), in 160 patients undergoing extraction of impacted lower third molar teeth. Test drugs were administered intravenously before surgery to provide postoperative analgesia. Following the operation, pain was assessed using a 10 cm visual analogue scale...

This randomized, double-blind, placebo-controlled, and comparator-controlled trial evaluated the safety and efficacy of an enzyme combination, as Wobenzym, in adults with moderate-to-severe osteoarthritis (OA) of the knee. Adults (n = 150) received Wobenzym, diclofenac (a nonsteroidal anti-inflammatory drug, NSAID), or placebo for 12 weeks. Improvement in pain scores (Lequesne Functional Index)...

Laser– assisted permanent hair removal iscommonly performed for the treatment of unwantedhair. This procedure is usually associated withpain and pain reduction has an important role inthe success of this treatment. A common methodof reducing pain is to use topical analgesics . Amixture of lidocaine and prilocaine (EMLA) is acommonly used and very effective topical anesthetic.Another agent is di...

OBJECTIVES To investigate the clinical efficacy and safety of a newly developed diclofenac patch in the topical treatment of blunt impact injuries. METHODS This was a randomised, placebo controlled, double blind, multicentre study in 120 patients with traumatic blunt soft tissue injury. Within 3 h of the injury participants of sport competitions and training camps were enrolled and treated tw...

In randomized controlled trials, medication side effects may lead to beliefs that one is receiving the active intervention and enhance active treatment responses, thereby increasing drug-placebo differences. We tested these hypotheses with an experimental double-blind randomized controlled trial of a nonsteroidal anti-inflammatory drug with and without the addition of atropine to induce side ef...

OBJECTIVE To evaluate the analgesic efficacy and safety of intramuscular drotaverine hydrochloride vs diclofenac sodium in treatment of acute renal colic. METHODS We conducted a randomized, single-blind study comparing single intramuscular doses of drotaverine hydrochloride (80 mg) vs diclofenac sodium (75 mg) on 100 patients (50 in each arm) presenting to the emergency department (ED) with r...

BACKGROUND Tonsillectomy is a common pediatric surgical procedure resulting in significant postoperative pain. There is ongoing controversy as to the most satisfactory analgesic regimen. Nonsteroidal antiinflammatory drugs (NSAIDs) are an alternative to opioids in this setting. NSAID use in tonsillectomy has been shown to be opioid sparing in the recovery period and to have similar analgesic ef...

BACKGROUND Acute musculoskeletal trauma, including strains, sprains or contusions, occur frequently. Pain management is a crucial component of treatment. However, there is no convincing evidence which drug is superior in managing pain in these patients. The aim of the PanAM Study is to compare analgesic efficacy of three strategies of pain management: paracetamol, diclofenac, or a combination o...

purpose: to evaluate the analgesic effect of topical sodium diclofenac 0.1% during pan-retinal photocoagulation (prp) in patients with proliferative diabetic retinopathy (pdr). methods: two-hundred informed patients (102 male, 98 female) with pdr were enrolled in this randomized controlled double-masked clinical trial. the treatment group received sodium diclofenac 0.1% eye drops and controls r...

CASE HISTORY A 52-yr-old female presented with complaints of upper abdominal pain, nausea and vomiting. There was no history of prior abdominal pain, abdominal distension and constipation. In June 2003, the patient had presented to her general practitioner with pain and swelling in multiple joints, both small and large. She was diagnosed to have seronegative rheumatoid arthritis and had receive...