Background. The fibrinolytic system is part of the defense against thrombotic and cardiovascular events, but so far no study has shown that clinical measurements of fibrinolytic key components such as tissue plasminogen activator (t-PA) or plasminogen activator inhibitor type 1 (PAI-1) have any predictive value beyond 3 years. Methods and Results. In 1983 through 1985, 213 consecutive patients ...

abstract background: while critical care nurses are vulnerable to burnout because of the complex nature of patients’ health problems, working in critical care areas has become even more complicated by shift working schedules. this study aimed to determine the relationship between fixed and rotating shifts and burnout in a sample of critical care nurses working in critical care areas. materials ...

Diacylglycerol (DAG) and phosphatidic acid (PA) are bioactive lipids synthesized when the T cell receptor binds to a cognate peptide-MHC complex. DAG triggers signaling by recruiting Ras guanyl-releasing protein 1, PKCθ, and other effectors, whereas PA binds to effector molecules that include mechanistic target of rapamycin, Src homology region 2 domain-containing phosphatase 1, and Raf1. While...

5-((4-alkoxyphenyl)azo)salicyladehyde, 5-((4-alkoxyphenyl)azo)-N-(npentyl, ndodecyl)-salicyladimine and bis [5-((4-alkoxyphenyl)azo)-N-(npentyl, ndodecyl)-salicyladiminato]copper(II) [alkoxy=OnCnH2n+1; n=3-7] homologues were synthesized and characterized by elemental analyses, mass and IR spectra. All complex homol...

The proteins, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1), act in concert to balance thrombus formation and degradation, thereby modulating the development of arterial thrombosis and excessive bleeding. PAI-1 is upregulated by the renin-angiotensin system (RAS), specifically by angiotensin II, the product of angiotensin converting enzyme (ACE) cleavage of a...

In this paper, we introduce a new hyperchaotic complex T-system. This system has complex nonlinear behavior which we study its dynamical properties including invariance, equilibria and their stability, Lyapunov exponents, bifurcation, chaotic behavior and chaotic attractors as well as necessary conditions for this system to generate chaos. We discuss the synchronization with certain and uncerta...

The purpose of this investigation was to assess the effect of captopril on both systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years) with HAPH and mild to moderate systemic arterial hypertension were included in the study. All patients underwent right heart catheterization with measurem...

Hypertension is associated with increased risk of thrombotic events including myocardial infarction and stroke. The endothelium plays an important role in limiting intravascular thrombosis, inhibiting coagulation and platelet aggregation, and promoting fibrinolysis. Hrafnkelsdottir et al1 have previously described impaired vascular tissue-type plasminogen activator (t-PA) release in individuals...