urrent oral antiplatelet therapy mainly targets the inhibition of cyclooxygenase-1 (COX-1) and the P2Y12 receptor in patients with acute coronary syndrome (ACS) and those treated with percutaneous coronary intervention (PCI).1 Despite proven clinical efficacy, the persistent ischemic event occurrence (≈10%) suggests that dual antiplatelet therapy (DAPT) has reached a ceiling in its effect in at...

The purpose of the present research work is prediction of electronic and physico-chemical properties of the novel medicinal compound Ticagrelor (AZD6140) using density functional theory (DFT) method. Firstly, its molecular structure was optimized at B3LYP/6-311++G(d,p) basis set of theory at room temperature. The global reactivity indices used to study the reactivity and stability of the title ...

In this study, the P2 receptor-mediated modulation of [3H]glutamate and [3H]noradrenaline release were examined in rat spinal cord slices. Adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), and 2-methylthioadenosine 5'-diphosphate (2-MeSADP) decreased the electrical stimulation-evoked [3H]glutamate efflux with the following order of potency: ADP>2-MeSADP>ATP. The effect of ATP was...