نتایج جستجو برای: p2x4 receptor p2x4r

تعداد نتایج: 590537  

Journal: :European journal of pharmacology 2013
Chao-Ying Li Ke-Ming Xiong Yu-Xiang Wu Yu-Wei Liu Lin Chen Randall R Stewart Robert W Peoples Chu-Li Yi

One feature of the amino acid sequence of P2X receptors identified from mammalian species, Xenopus laevis and zebrafish is the conservation of ten cysteines in the extracellular loop. Little information is available about the role of these conserved ectodomain cysteines in the function of P2X receptors. Here, we investigated the possibility that ten conserved cysteine residues in the extracellu...

2017
Yuta Shiozaki Masaki Sato Maki Kimura Toru Sato Masakazu Tazaki Yoshiyuki Shibukawa

ATP modulates various functions in the dental pulp cells, such as intercellular communication and neurotransmission between odontoblasts and neurons, proliferation of dental pulp cells, and odontoblast differentiation. However, functional expression patterns and their biophysical properties of ionotropic ATP (P2X) receptors (P2X1-P2X7) in odontoblasts were still unclear. We examined these prope...

Journal: :Blood 2010
Tobias Woehrle Linda Yip Abdallah Elkhal Yuka Sumi Yu Chen Yongli Yao Paul A Insel Wolfgang G Junger

Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR) stimulation at the immune synapse. We previously reported that TCR stimulation induces the release of cellular adenosine-5'-triphosphate (ATP) that regulates T-cell activation. Here we tested the roles of pannexin-1 hemichannels, which have been implicated in ATP release, and of various P2X receptors, which serve...

2014
Li-Dong Huang Ying-Zhe Fan Yun Tian Yang Yang Yan Liu Jin Wang Wen-Shan Zhao Wen-Chao Zhou Xiao-Yang Cheng Peng Cao Xiang-Yang Lu Ye Yu

P2X receptors are ATP-gated ion channels involved in many physiological functions, and determination of ATP-recognition (AR) of P2X receptors will promote the development of new therapeutic agents for pain, inflammation, bladder dysfunction and osteoporosis. Recent crystal structures of the zebrafish P2X4 (zfP2X4) receptor reveal a large ATP-binding pocket (ABP) located at the subunit interface...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2006
V H J Roberts S L Greenwood A C Elliott C P Sibley L H Waters

Appropriate regulation of ion transport by the human placental syncytiotrophoblast is important for fetal growth throughout pregnancy. In nonplacental tissues, ion transport can be modulated by extracellular nucleotides that raise intracellular calcium ([Ca2+]i) via activation of purinergic receptors. We tested the hypothesis that purinergic receptors are expressed by human placental cytotropho...

Journal: :Current medicinal chemistry 2015
Leanne Grimes Mark T Young

The publication of the first crystal structures of the zebrafish P2X4 receptor in 2009 was a pivotal moment; for the first time, researchers were able to interpret their experimental data in a structural context. Several research groups immediately set about using the data to make molecular models of the better-understood mammalian P2X receptors, in order to design and interpret the results of ...

Journal: :Neuroscience 2015
J Sábado A Casanovas H Rodrigo G Arqué J E Esquerda

Previous reports from our lab had shown that some anti-purinergic receptor P2X4 antibodies cross-reacted with misfolded forms of mutant Cu/Zn superoxide dismutase 1 (SOD1), linked to amyotrophic lateral sclerosis (ALS). Cross-reactivity could be caused by the abnormal exposure of an epitope located in the inner hydrophobic region of SOD1 that shared structural homology with the P2X4-immunizing ...

2016
Makoto Tsuda

In contrast to physiological pain, pathological pain is not dependent on the presence of tissue-damaging stimuli. One type of pathological pain - neuropathic pain - is often a consequence of nerve injury or of diseases such as diabetes. Neuropathic pain can be agonizing, can persist over long periods and is often resistant to known painkillers. A growing body of evidence shows that many patholo...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید