نتایج جستجو برای: p15 gene

تعداد نتایج: 1142253  

2013
Glyn Chidlow John P. M. Wood Shiwani Sharma David P. Dimasi Kathryn P. Burdon Robert J. Casson Jamie E. Craig

It has recently been shown that there are highly significant associations for common single nucleotide polymorphisms (SNPs) near the CDKN2B-AS1 gene region at the 9p21 locus with primary open angle glaucoma (POAG), a leading cause of irreversible blindness. This gene region houses the CDKN2B/p15(INK4B) , CDKN2A/p16(INK4A) and p14ARF (rat equivalent, p19(ARF) ) tumour suppressor genes and is adj...

Journal: :Annals of hepatology 2015
Jin-Ching Lin Yao-Chung Wu Cheng-Chung Wu Pei-Yin Shih Wen-Yi Wang Yi-Chih Chien

INTRODUCTION Hypermethylation of relevant genes may affect the prognosis of patients with cancer. The purpose of this study was to analyze whether methylation of the promoter regions of cell cycle regulators as well as elevated α-Fetoprotein (AFP) levels are useful prognostic factors for patients with hepatocellular carcinoma (HCC). MATERIAL AND METHODS Nested methylation-specific PCR (nested...

Journal: :Blood 2011
Esperanza Such José Cervera Ana Valencia Eva Barragán Mariam Ibañez Irene Luna Oscar Fuster Maria Luz Perez-Sirvent Leonor Senent Amparo Sempere Jesús Martinez Guillermo Martín-Aragonés Miguel A Sanz

Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative geno...

2014
Ching-Chun Yang Er-Yi Huang Hung-Cheng Li Pei-Yi Su Chiaho Shih

Hepatitis B virus (HBV) core protein (HBc) can shuttle between nucleus and cytoplasm. Cytoplasm-predominant HBc is clinically associated with severe liver inflammation. Previously, we found that HBc arginine-rich domain (ARD) can associate with a host factor NXF1 (TAP) by coimmunoprecipitation. It is well known that NXF1-p15 heterodimer can serve as a major export receptor of nuclear mRNA as a ...

Journal: :Journal of bacteriology 2002
Pia S Rydman Dennis H Bamford

Bacteriophage PRD1 encodes two proteins (P7 and P15) that are associated with a muralytic activity. Protein P15 is a soluble beta-1,4-N-acetylmuramidase that causes phage-induced host cell lysis. We demonstrate here that P15 is also a structural component of the PRD1 virion and that it is connected to the phage membrane. Small viral membrane proteins P20 and P22 modulate incorporation of P15 in...

Journal: :Cancer research 2002
Takeshi Taketani Tomohiko Taki Noriko Shibuya Etsuro Ito Junichi Kitazawa Kiminori Terui Yasuhide Hayashi

The nucleoporin gene, NUP98, has been reported to be fused to seven partner genes in hematological malignancies with 11p15 translocations. We report here a novel NUP98 partner gene, HOXD11, not HOXD13, in a pediatric patient with de novo AML having t(2;11)(q31;p15), using a cDNA panhandle PCR. The HOXD11 gene is one of the HOXD cluster genes and contains 2 exons, encoding a protein of 338 amino...

Journal: :Journal of virology 2005
Sandra Dawe Jennifer A Corcoran Eileen K Clancy Jayme Salsman Roy Duncan

Select members of the Reoviridae are the only nonenveloped viruses known to induce syncytium formation. The fusogenic orthoreoviruses accomplish cell-cell fusion through a distinct class of membrane fusion-inducing proteins referred to as the fusion-associated small transmembrane (FAST) proteins. The p15 membrane fusion protein of baboon reovirus is unique among the FAST proteins in that it con...

Journal: :Bioscience, biotechnology, and biochemistry 2003
Satoru Nakashima Shuji Wakatsuki Tatsuya Yokoyama Manabu Arioka Katsuhiko Kitamoto

We previously showed that a fungal protein, p15, induces neurite outgrowth and differentiation of rat pheochromocytoma PC12 cells. We report here the identification and characterization of a protein similar to p15, found in Streptomyces coelicolor A3(2). This hypothetical protein, tentatively named Scp15, has significant similarity with p15, including conserved positions of four cysteine residu...

Journal: :Journal of virology 1981
S Maxwell R B Arlinghaus

Moloney murine leukemia virus, disrupted in concentrations of 0.1 to 0.5% Nonidet P-40, catalyzed the cleavage of p65, the gag gene polyprotein of the Gazdar strain of murine sarcoma virus, into polypeptides with sizes and antigenic determinants of murine leukemia virus-specified p30, p15, pp12, and p10. Cleavage performed in the presence of 0.15% Nonidet P-40 in water yielded polypeptides of a...

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