Purpose: Respiratory diseases are one of the main causes of death worldwide [1] and a lot of effort is undertaken to develop new techniques to assess lung function. Using hyperpolarized (HP) He-MRI it is possible to locally measure the alveolar partial pressure of oxygen (pO2) and its temporal evolution during apnea [2]. Most of the pO2 measurement approaches currently used in humans and animal...

Genetic deficiency or instability of myelin protein zero (P0) results in hereditary motor sensory neuropathy. In view of recent advances in gene therapy, substitution of the molecular defect may become realistic in the near future. Here we investigate the impact of genetic deficiency of P0 on selection of the autoreactive T cell repertoire in the corresponding mouse model. We show that P0 mRNA ...

BACKGROUND Examining the role of modifiable barriers and facilitators is a necessary step toward developing effective implementation strategies. This study examines whether both general (organizational culture, organizational climate, and transformational leadership) and strategic (implementation climate and implementation leadership) organizational-level factors predict therapist-level determi...

Physicians are drawn into diverse leadership roles in academic medicine, but little in our education and training prepares us for these responsibilities. Fortunately, there is growing convergence in the literature on the attributes of successful leaders for knowledge-based organisations. Top-performing leaders seem to be self-effacing team-builders who eschew rapid-cycle strategic planning and ...

In this month's column, Stephanie Ferguson, PhD, RN, FAAN, Director, International Council of Nurses' (ICN) Leadership for Change Programme; Facilitator, ICN Global Nursing Leadership Institute; ICN Consultant for Nursing and Health Policy; and World Health Organization Consultant, provides a perspective on the importance of global nursing excellence and highlights the American Nurses Credentia...

An apparent gap in mainstream strategy literature points to questions relating to the role and competencies of leaders in strategy making. An initial investigation reveals that turbulent change and growing environmental uncertainty demands leadership intuition and skills that are able to anticipate aspects of the future, provide enabling environments significantly different to the recent past a...

nowadays, organizations are active in dynamic environments filled with changes and transformation. the requirement for surviving in such a situation is to create continuous organizational changes and upheavals, whether in behavioral dimension or structural one. in these organizational changes and upheavals, leadership and management have a determining role. therefore, the existence of knowledge...

1. Note that Y1 is independent of {Xn}n=1. Now, observe that H0 is a composite hypothesis, and we are in a Bayesian situation with the rv θ (= the rv P0) taking values in Θ0 = {1/4, 3/4} with P0[θ = 1 4 ] = 14 = 1 − P0[θ = 34 ], where P0 denotes the conditional pmf of θ given H = H0. H1 is a simple hypothesis. Under H0: For each t ∈ Θ0 = { 1 4 , 4}, {Yn}n=1 is a 1st order Markov process with tr...