Aims Prescription drug misuse in the USA increased during 1990s to 2010. The epidemic stimulated need new analytical strategies and techniques understand medications involved, user characteristics other factors needed address epidemic. Methods A strategy of mosaic surveillance has evolved. Using real world evidence, goal is paint a more complete profile drug's using triangulation—integrating re...

BACKGROUND Evaluation of tamper resistant formulations (TRFs) and classwide Risk Evaluation and Mitigation Strategies (REMS) for prescription opioid analgesics will require baseline descriptions of abuse patterns of existing opioid analgesics, including the relative risk of abuse of existing prescription opioids and characteristic patterns of abuse by alternate routes of administration (ROAs). ...

BACKGROUND Overprescribing of opioid pain relievers (OPR) can result in multiple adverse health outcomes, including fatal overdoses. Interstate variation in rates of prescribing OPR and other prescription drugs prone to abuse, such as benzodiazepines, might indicate areas where prescribing patterns need further evaluation. METHODS CDC analyzed a commercial database (IMS Health) to assess the ...

As pharmacogenomics makes further advances into clinical practice, the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines provide considerable assistance in clinical decision making. The new 2014 CPIC guidelines on CYP2D6 and codeine (1 ) have an update on considerations for clinicians and healthcare providers. The previous CPIC guidelines provided recommendations primarily o...