introduction: the role of ovarian hormones and nitric oxide (no) on oxidative damage in brain tissues as well as learning and memory has been widely investigated.the present study was carried out to evaluate the effect of the precursor of no, l-arginine on learning and brain damage due to oxidative stress in ovariectomized (ovx) rats.methods: thirty -two rats were divided into four groups: 1) s...

background: diabetes is one of the most common metabolic disorders and is related to oxidative-stress-induced diseases. given the role of dietary antioxidants in the control and prevention of diabetes, this study aimed to examine the effects of sesame butter versus sesame oil on the serum levels of glucose, lipid profile, and oxidative stress biomarkers in diabetic rats. methods: forty male alb...

conclusions beta-alanine supplementation has limited antioxidant effect during the repeated wts. background carnosine is a dipeptide formed from the β-alanine and histidine amino acids and found in mainly in the brain and muscle, especially fast twitch muscle. carnosine and creatine has an antioxidant effect and carnosine accounts for about 10% of the muscle's ability to buffer the h+ ions prod...

objective(s): oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. licochalcone b, an extract of licorice root, has shown antioxidative properties. this study was to investigate the effects and mechanisms of licochalcone b in ethanol-induced hepatic injury in an in vitro study. materials and methods: an in vitro model of ethanol-induced cytotoxicity in brl cel...

introduction: this study aimed to evaluate the effect of short-term creatine supplementation on oxidative stress and antioxidant enzymes after six bouts of 50-meter sprint swimming. methods: this quasi-experimental study recruited eight trained female swimmers with the mean age of 25±4.4 years and body mass index (bmi) of 21.8±4.2 kg/m2 to perform six bouts of 50-meter sprint swimming with a 12...

objective(s): hyperglycemia, oxidative stress and apoptosis have key roles in pathogenesis of diabetic neuropathy. there are local renin-angiotensin systems (rass) in different tissues such as neural tissue. local rass are involved in physiological and pathophysiological processes such as inflammation, proliferation and apoptosis. this study aimed to investigate the role of local renin-angioten...

objective(s):a growing interest has recently been attracted towards the identification of plant-based medications including those with protective effects against cognitive impairment. sesamol has shown promising antioxidant and neuroprotective effects, therefore, we aimed to evaluate its therapeutic potential in epilepsy which is commonly associated with oxidative stress and cognitive impairmen...

objective(s): crocin influences many biological functions including memory and learning. the present study was aimed to investigate the effects of crocin on learning and memory impairments in streptozotocine-induced diabetic rats. materials and methods: diabetes was induced by intraperitoneal (ip) injection of streptozotocin (stz, 45 mg/kg). transfer latency (tl) paradigm in elevated plus-maze ...

parkinson`s disease (pd) is the second most common neurodegenerative disorder after alzheimer`s disease. it is a chronic and progressive disease, and mostly afflicts elderlies. pd starts with sudden onsets and the exact cause of the disease is still unknown, however there are some early symptoms that can help us to diagnose the disease and ameliorate its effects. pd is a multi-factorial disease...

background: the aim of this study was to investigate the effects of leishmania major infection on the induction of oxidative stress in skin and lung of female mice. methods: balb/c mice were randomly divided into the control and experi-mental groups. the experimental groups were subcutaneously infected with in-oculums promastigotes of l. major . the animals were sacrificed at 20, 40, 60, 90 and...