background: diabetes mellitus in some clinical cases is accompanied with hyperalgesia. in this study, we evaluated the possible beneficial effect of chronic pelargonidin (pg) treatment on hyperalgesia in streptozotocin (stz)-diabetic neuropathic rat. methods: male wistar rats (n = 56) were divided into seven groups, i.e. control, diabetic, pg-treated control, pg (single- and multiple-dose)-trea...

This is the first comprehensive study to evaluate the cytotoxicity, biochemical mechanisms of toxicity, and oxidative DNA damage caused by exposing human bronchoalveolar carcinoma-derived cells (A549) to 70 and 420 nm ZnO particles. Particles of either size significantly reduced cell viability in a doseand time-dependent manner within a rather narrow dosage range. Particle massbased dosimetry a...

The distribution of hydrogen and how this can be widely achieved plays a significant role in the transition from fossil fuels to clean fuel. Using existing natural gas pipeline network suitable option for countries with extensive infrastructure. This study is aimed at investigating compatibility polyethylene (PE) pipe hydrogen. paper utilises cyclic pennsylvania edge notch test (CPENT) method t...

Increased mesangial cell proliferation is a hallmark of many glomerulopathies in humans. Whereas the pathogenic role of reactive oxygen species (ROS) in the development of experimental mesangioproliferative glomerulonephritis (GN) is well established, very little is known about the mechanisms leading to increased ROS concentrations in the glomerulus. This study therefore examined glomerular ROS...

Abstract This study demonstrates that bio-based products of lignin depolymerisation can potentially replace common antioxidants and UV absorbers in the plastics cosmetics industries. The kraft Indulin AT was used to obtain low-MW monomers & oligomers rich phenolic hydroxyl groups. Both thermo-oxidative stability antioxidant activity significantly improved upon depolymerisation. results from...

Arsenic trioxide (As2O3) has been introduced to the treatment of acute promyelocytic leukemia (APL), and has also been shown to induce apoptosis in a variety of solid tumor cell lines, including non-small cell lung cancer. However, the prohibitively high concentration required for the induction of apoptotic cell death in many solid tumor cells is unacceptable for clinical utilization due to the...

In this review, we discuss studies on the role of CYP2E1 in alcohol-induced oxidative stress and how MAPK signaling cascades are involved in alcohol induced liver injury and fat accumulation. Many pathways have been suggested to play a role in how alcohol induces oxidative stress. Considerable attention has been given to alcohol elevated production of lipopolysaccharide (LPS) and TNFα and to al...

Cytochrome P450 2A6 (CYP2A6) is known to metabolize nicotine, the major constituent of tobacco, leading to the production of toxic metabolites and induction of oxidative stress that result in liver damage and lung cancer. Recently, we have shown that CYP2A6 is induced by ethanol and metabolizes nicotine into cotinine and other metabolites leading to generation of reactive oxygen species (ROS) i...