Molecular oxygen is involved in the propagation step of this reaction, and it is an integral part of the catalytic cycle that generates the oxidative degradation of drug substances in pharmaceutical formulations. Oxidative degradation of the active drug substance in a formulation decreases drug potency and reduces product shelf life (2). The rate of oxidative degradate formation is proportional...

We have studied the effect of propofol on the enzymatic degradation of alfentanil and sufentanil utilizing isolated liver microsomes obtained from pig and human liver. Propofol inhibited dose-dependently the oxidative metabolic degradation of alfentanil and sufentanil by both microsomal preparations. The calculated concentration of propofol causing 50% inhibition of metabolic degradation (IC50)...

An HPLC method for determination of mebeverine hydrochloride (MH) in the presence of its degradation products was developed. The degradation of MH was studied under hydrolysis, oxidative and photolysis stress conditions. Under alkaline, acidic and oxidative conditions, degradation of MH was observed. The separation was performed using a Symmetry C18 column and a mixture of 50 mM KH2PO4, acetoni...

An ethylene carbonate-free electrolyte composed of 1 M lithium bis(fluorosulfonyl) imide (LiFSI) in sulfolane (SL) is studied here for LiNi0.5Mn1.5O4-graphite full-cells. important focus on the evaluation anodic stability SL and passivation layers formed LiNi0.5Mn1.5O4 (LNMO) graphite being analysed along with intermittent current interruption (ICI) technique to observe resistance while cycling...

The oxidative degradation of phenol via in situ H 2 O production offers an attractive route to the destruction organic contaminants water streams, overcoming significant concerns associated with traditional remediation technologies.

Low-temperature tenderization is an important aspect in the processing of sea cucumber. Oxidative reactions induce protein aggregation or degradation during thermal treatment. However, whether oxidation occurs cucumber unclear. Moreover, effects heat treatment on structure have not been well explored. In this study, Apostichopus japonicus body wall (AJBW) were tenderized at 37 °C and changes mi...

Iron(III)-NTA (nitrilotriacetic acid) solution shows high activity for oxidative degradation of 2'-deoxyribose in the presence of hydrogen peroxide, whereas its activity of Fe(III)-TFD A (2-aminomethyltetrahydrofuran-N,N-diacetic acid) is negligible under the same experimental conditions; however the latter solution exhibits abnormally higher reactivity for oxygenation reaction at 8-position of...

Hyperphosphorylated tau proteins accumulate in the paired helical filaments of neurofibrillary tangles seen in such tauopathies as Alzheimer's disease. In the present paper we show that tau turnover is dependent on degradation by the proteasome (inhibited by MG132) in HT22 neuronal cells. Recombinant human tau was rapidly degraded by the 20 S proteasome in vitro, but tau phosphorylation by GSK3...