Copy-number variation (CNV) is the most prevalent type of structural variation in the human genome. There is emerging evidence that copy-number variants (CNVs) provide a new vista on understanding susceptibility to neuropsychiatric disorders. Some challenges in the interpretation of current CNV studies include the use of overlapping samples, differing phenotypic definitions, an absence of popul...

CD8+ T cells are important for HIV-1 virus control, but are also a major contributing factor that drives HIV-1 virus sequence evolution. Although HIV-1 cytotoxic T cell (CTL) escape mutations are a common aspect during HIV-1 infection, less is known about the importance of T cell pressure in reversing HIV-1 virus back to a consensus sequences. In this study we aimed to assess the frequency with...

This paper compares a new algorithm with two well-known algorithms for precise alignment of overlapping adjacent images. The new part of the algorithm is concerned with the selection of exactly matching pairs of feature points in the two images and its performance is compared with the performance of the Least Median of Square regression algorithm (LMedS), and the Random Sample Consensus (RANSAC...

Geometric realization of opinion is considered as a simplex and the opinion space of a group of individuals is a simplicial complex whose topological features are monitored in the process of opinion formation. The agents are physically located on the nodes of the scale-free network. Social interactions include all concepts of social dynamics present in the mainstream models augmented by four ad...

Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1 sequences to stimulate and detect T-cell responses ex vivo. These "HLA-optimised" peptides captured more HIV-1 Nef-specific responses compared...

The DARPA MOSAIC program applies multiscale optical design (shared objective lens and parallel array of microcameras) to the acquisition of high pixel count images. Interestingly, these images present as many challenges as opportunities. The imagery is acquired over many slightly overlapping fields with diverse focal, exposure and temporal parameters. Estimation of a consensus image, display of...

Introduction: Myofibroblastic sarcoma is designated as a low-grade malignancy, commonly affecting the deep soft tissue of head and neck. Despite being classified low-grade, myofibroblastic with high-grade features have been reported. Observations: Two such cases oral cavity, which were diagnosed different entities upon biopsy, observed. Case 1 presented multiple, well-circumscribed swellings to...

Objective After the recent publication of the first patients with disease-associated missense variants in the GRIN2D gene, we evaluate the effect of copy number variants (CNVs) overlapping this gene toward the presentation of neurodevelopmental disorders (NDDs). Methods We explored ClinVar (number of CNVs = 50,794) and DECIPHER (number of CNVs = 28,085) clinical databases of genomic variation...

Although it contains binding sites for HNF1, NFY and C/EBP/DBP, the proximal promoter of the aldolase B gene is surprisingly weak when tested by transient transfection in differentiated hepatoma cells. This low activity could be due to overlapping between HNF1 and HNF3 binding sites in element PAB, from -127 to -103 bp with respect to the cap site. Replacement of the PAB region by a consensus H...