Bladder tumors represent a special therapeutic challenge as they have a high recurrence rate requiring repeated interventions and may progress to invasive or metastatic disease. Exosomes carry proteins implicated in bladder cancer progression and have been implicated in bladder cancer cell survival. Here, we characterized exosome uptake and internalization by human bladder cancer cells using Am...

Van Asselt, Els, Joost le Feber, and Ron van Mastrigt. Threshold for efferent bladder nerve firing in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1819–R1824, 1999.—In this study, the mechanism involved in the initiation of voiding was investigated. Bladder pressure and bladder and urethral nerve activity were recorded in the anesthetized rat. Bladder nerve activity...

OBJECTIVES To evaluate the effects of propiverine and its active metabolites (M-1 and M-2) on bladder function through modulation of afferent activity in rats. METHODS Cystometry was performed in urethane anesthetized female rats. We examined the effects of intravesical administration of propiverine, M-1 and M-2 on bladder overactivity induced by oxotremorine-M (Oxo-M; non-selective mAChR ago...

PURPOSE Bladder cancer is the fifth most common malignancy in men in Western society. We determined RAS codon 12 and 13 point mutations and evaluated mRNA expression levels in transitional cell carcinoma cases. MATERIALS AND METHODS Samples from 30 human bladder cancers and 30 normal tissues were analyzed by polymerase chain reaction/restriction fragment length polymorphism and direct sequenc...

The new highly active supported vanadium-magnesium catalyst (VMC) has been studied in α-olefin (1-butene, 1-hexene)/ ethylene copolymerization in the presence of hydrogen. Data on the effect of α-olefin/ethylene ratio in copolymerization on the content of branchings in copolymers, kinetic profile, copolymer yield, molecular weight and molecular weight distribution of copolymers have been obtain...

Introduction. Traditionally it is believed that the therapeutic effect of hexane extract Serenoa repens (HSRE) in patients with benign prostatic hyperplasia realized due to its on prostate cells. However, literature there data about possible HSRE not only prostate, but also directly bladder. This paper summarizes and analyzes cellular mechanisms action bladder under development infravesical obs...

Bladder cancer is the fourth most common cancer in men in the United States, after prostate, lung, and colorectal cancer and the 10th most common cancer in women [1]. From 1985-2000, the number of patients diagnosed annually with bladder cancer has increased by 33%. The recurrence rate for superficial transitional cell cancer of the bladder is high and as many as 80% of patients have at least o...

The transfer of certain electrolytes (Na22, C136, K42 and P3204) from the isolated urinary bladder to the plasma compartment was studied in the dog. The rate of transfer was shown to be a function of the PH of the bladder contents over a range of 5 through 8. It was also shown that the rate of transfer was decreased by addition of common ion. Na22 and C136 showed greater rates of transfer than ...