Background Studies show that proallergic TH2 cells decrease after successful allergen-specific immunotherapy (AIT). It is likely iatrogenic administration of allergens drives these to exhaustion due chronic T-cell receptor stimulation. This study aimed investigate the T in connection with allergen exposure during AIT mice and two independent patient cohorts. Methods OVA-sensitized C57BL/6J were...

Ovalbumin (OVA) is the major allergenic protein that can induce T helper 2 (Th2)-allergic reactions for which current treatment options are inadequate. In this study, we developed a polymerized hypoallergenic OVA product via laccase/caffeic acid (Lac/CA)-catalyzed crosslinking in conjunction with galactomannan (Man). The formation of high molecular weight crosslinked polymers and IgG-binding we...

Epitope peptides are not suitable for nasal administration immunity due to their poor immunogenicity and low delivery efficiency. Here, we reported an intranasal self-assembled nanovaccine (I-OVA NE), which was loaded with the IKVAV-OVA257–264 (I-OVA), a laminin peptide (Ile-Lys-Val-ala-Val, IKVAV) OVA257–264 epitope conjugated peptide. This I-OVA at concentration of 4 mg/mL showed average part...

There are conflicting data to support the practice of delaying the introduction of allergenic foods into the infant diet to prevent allergy development. This study investigated immune response development after early oral egg antigen (Ovalbumin; OVA) exposure in a rat pup model. Brown Norway (BN) rat pups were randomly allocated into groups: dam reared (DR), DR pups challenged daily (days 4-13)...

BACKGROUND AND PURPOSE We have previously shown that bisphenol A (BPA) augments T-helper (Th) 1 activity with no significant effects on an established oral tolerance to ovalbumin (OVA) in mice fed with a normal protein diet. The present study aimed to examine the effect of BPA on the immune response in a mouse model maintained on a very low protein diet (5% casein). METHODS Mice were fed on a...

Azadirachta indica Linn (A. indica), is a marvelous traditional Indian medicine with key therapeutics role in health management. Studies have revealed the anti-inflammatory, immunomodulatory and antioxidative of A. indica. Inflammatory immune cells generate high level ROS for stimulated severe AHR airway inflammation. Therefore, present study designed to investigate ameliorating potentiality le...

background: conventional wastewater treatment is a combination of physical and biological processes designed to remove organic matter from solution. waste sludge drawn from these processes is thickened and processed for ultimate disposal wastewater contains various kinds of infectious agents, such as bacteria, viruses, fungi and parasites. correct treatment in wastewater treatment plants is imp...

Archaeal isopranoid glycerolipid vesicles (archaeosomes) serve as strong adjuvants for cell-mediated responses to entrapped Ag. We analyzed the processing pathway of OVA entrapped in archaeosomes composed of Methanobrevibacter smithii lipids, high in archaetidylserine (OVA-archaeosomes). In vitro, OVA-archaeosomes stimulated spleen cells from OVA-TCR-transgenic mice, D011.10 (CD4(+) cells expre...

In this study, the biopolymeric fraction BOS 2000 from Boswellia serrata was evaluated for its potential ability as adjuvants on the immune responses to ovalbumin (OVA) in mice. Balb/c mice were immunized subcutaneously with OVA 100 μg alone or with OVA 100 μg dissolved in saline containing alum (200 μg) or BOS 2000 (10, 20, 40 and 80 μg) on Days 1 and 15. Two weeks later, OVA specific antibodi...

El objetivo de este trabajo es identificar la eficacia los objetos virtuales aprendizaje (OVA) en adquisición competencias química entre alumnos primer año dos universidades Coquimbo, Chile, y evaluar el desarrollo para empleo vida sociedad. La investigación se circunscribe a una metodología cuasiexperimental pre post test con grupo control. Los instrumentos utilizados cuentan un índice Alfa Cr...