PURPOSE In vivo, biomechanical stress plays an important role in tissue physiology and pathology, affecting cell and tissue behavior. Even though conventional outflow tissues are constantly exposed to dynamic changes in intraocular pressure, effects of such biomechanical stressors on outflow function have not been analyzed. The purpose of the present study was to determine the effect(s) of ocul...

Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a m...

OBJECTIVE To investigate the spectrum of pulmonary atresia and critical pulmonary stenosis using right ventricular outflow tract angiography and explore its implications for catheter interventional treatment. DESIGN Prospective clinical study. SETTING Two paediatric cardiology centres. SUBJECTS 11 neonates or infants (aged 1 day to 8 months; weighing 2.3 to 7.8 kg) with pulmonary atresia ...

[1] The meteorological pathways contributing to Asian pollution outflow over the Pacific are examined with a global three-dimensional model analysis of CO observations from the Transport and Chemical Evolution over the Pacific (TRACE-P) aircraft mission (February–April 2001). The model is used also to place the TRACE-P observations in an interannual (1994–2001) and seasonal context. The major p...

We determined the effect of chronic and acute loss of glycosaminoglycans from the aqueous outflow pathway on intraocular pressure (IOP) and outflow facility in the subhuman primate eye. For the study of the chronic effects of the GAGases, cynomolgus monkeys received intracameral injections of hyaluronidase (Streptomyces, 5 or 50 units, n=2) or chondroitinase ABC (0.05 or 0.25 units, n=2) biweek...

PURPOSE To investigate the effect of 180° versus 360° primary selective laser trabeculoplasty (SLT) on tonographic outflow facility and intraocular pressure (IOP). DESIGN Prospective, single masked randomised clinical trial. PARTICIPANTS Patients with untreated primary open angle glaucoma or ocular hypertension both with IOP > 21-35 mmHg. METHODS 40 patients randomly treated with 180° or ...

Using CARMA, we imaged the 87 GHz SiO v=0 J=2-1 line toward Orion-KL with 0.45 angular resolution. The maps indicate that radio source I drives a bipolar outflow into the surrounding molecular cloud along a NE–SW axis, in agreement with the model of Greenhill et al. (2004). The extended high velocity outflow from Orion-KL appears to be a continuation of this compact outflow. High velocity gas e...

Relativistic neutron-loaded outflows in gamma-ray bursts are studied at their early stages, before deceleration by a surrounding medium. The outflow has four components: radiation, electrons, protons and neutrons. The components interact with each other and exchange energy as the outflow expands. The presence of neutrons significantly changes the outflow evolution. Before neutrons decouple from...

We describe two cases of left ventricular outflow tract obstruction after mitral valve replacement with complete retention of the subvalvular apparatus. The first patient deteriorated immediately after insertion of a high-profile bioprosthesis. In the second patient, chronic left ventricular outflow tract obstruction developed after the insertion of a low-profile mechanical prosthesis. The clin...

PURPOSE To determine whether H-7 can enhance outflow facility after trabecular meshwork obstruction by extracellular material that accumulates after long-term treatment of monkeys with the cholinesterase inhibitor echothiophate iodide (ECHO). METHODS Cynomolgus monkeys were treated topically with 150 microg ECHO in one (n = 4 eyes) or both (n = 8 eyes) eyes for up to 48 weeks. Accommodation r...