نتایج جستجو برای: osm
تعداد نتایج: 1085 فیلتر نتایج به سال:
Matricellular proteins in the kidney have been associated with the development of tubulointerstitial fibrogenesis and the progression of renal disease. This study investigated potential antifibrotic effects of the cytokine oncostatin M (OSM) in human proximal tubule cells (PTC), particularly with regard to inhibition of profibrotic events initiated by TGF-β1. In human PTC, OSM diminished transf...
BACKGROUND The conserved DOS-motif proteins OSM-7 and OSM-11 function as coligands with canonical DSL (Delta, Serrate, and LAG-2) ligands to activate C. elegans Notch receptors during development. We report here that Notch ligands, coligands, and the receptors LIN-12 and GLP-1 regulate two C. elegans behaviors: chemosensory avoidance of octanol and quiescence during molting lethargus. RESULTS...
Volunteered Geographic Information (VGI) such as data derived from the OpenStreetMap (OSM) project is a popular data source for freely available geographic data. Normally, untrained contributors gather these data. This fact is frequently a cause of concern regarding the quality and usability of such data. In this study, the quality of OSM land use and land cover (LULC) data is investigated for ...
OpenStreetMap (OSM) represents one of the most well-known examples of a collaborative mapping project. Major research efforts have so far dealt with data quality analysis but the modality of OSM’s evolution across space and time has barely been noted. This study aims to analyze spatio-temporal patterns of contributions in OSM by proposing a contribution index (CI) in order to investigate the dy...
OBJECTIVES It is believed that adipose tissue acts as an endocrine organ by producing inflammatory mediators and thereby contributes to the increased cardiovascular risk seen in obesity. A link between adipose tissue mass and angiogenesis has been suggested. Vascular endothelial growth factor (VEGF) seems to be implicated in this process. Members of the glycoprotein (gp)130 ligand family regula...
Rheumatoid arthritis (RA), a common autoimmune disorder, is associated with a chronic inflammatory response and unbalanced bone metabolism within the articular microenvironment. Adiponectin, an adipokine secreted by adipocytes, is involved in multiple functions, including lipid metabolism and pro-inflammatory activity. However, the mechanism of adiponectin performance within arthritic inflammat...
In Volunteered Geographic Information (VGI) projects, the tagging or annotation of objects is usually performed in a flexible and non-constrained manner. Contributors to a VGI project are normally free to choose whatever tags they feel are appropriate to annotate or describe a particular geographic object or place. In OpenStreetMap (OSM), the Map Features part of the OSM Wiki serves as the de-f...
Tissue inhibitor of metalloproteinases-1 (TIMP-1) can be regulated by gp130 cytokines such as IL-6 and oncostatin M (OSM). Polymerase chain reaction deletion analysis of the murine TIMP-1 proximal promoter in chloramphenicol acetyltransferase reporter gene constructs identified an AP-1 element (-59/-53) that allows maximal responsiveness to OSM in HepG2 cells. Fos and Jun nuclear factors bound ...
Oncostatin M (OSM) is a pleiotropic cytokine of the IL-6 family and displays both pro-inflammatory and anti-inflammatory activities. We studied the impact of OSM on the gene activation profile of human synovial cells, which play a central role in the progression of inflammatory responses in joints. In synovial cells stimulated with lipopolysaccharide and recombinant human granulocyte-macrophage...
Assessing the Completeness of Bicycle Trail and Lane Features in OpenStreetMap for the United States
This paper assesses the completeness of bicycle trail and on-street lane features in OpenStreetMap (OSM). Comparing OSM cycling features with reference data from local planning agencies for selected US Urbanized Areas shows that OSM bicycle trails tend to be more completely mapped than bicycle lanes. Manual evaluation of mapped cycling features in OSM and Google Maps for selected test areas wit...
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