Although the behaviour of fluid-filled vesicles in steady flows has been extensively studied, far less is understood regarding shape dynamics time-dependent oscillatory flows. Here, we investigate nonlinear large amplitude extensional (LAOE) using both experiments and boundary integral (BI) simulations. Our results characterize transient membrane deformations, dynamical regimes stress response ...

The hypothesis that respiratory modulation due to upper airway (UA) pressure and flow is dependent on stimulus modality and respiratory phase-specific activation was assessed in anesthetized, tracheotomized, spontaneously breathing piglets. Negative pressure and flow applied to the isolated UA at room or body temperature during inspiration only enhanced posterior cricoarytenoid muscle activity ...

An understanding of flow and dispersion in the human respiratory airways is necessary to assess the toxicological impact of inhaled particulate matter as well as to optimize the design of inhalable pharmaceutical aerosols and their delivery systems. Secondary flows affect dispersion in the lung by mixing solute in the lumen cross section. The goal of this study is to measure and interpret these...