نتایج جستجو برای: osc pls

تعداد نتایج: 12724  

Journal: :IOP conference series 2023

Abstract This study aims to assess Near infrared (NIR) spectroscopy predict vanillin and moisture content non-destructively. Twenty-four samples of vanilla pods (@55 grams/sample) from Sumatra Sulawesi Island were tested. The reflectance spectra pod measured using a NIRFlex N-500 spectrometer at the wavelength 1000-2500 nm. After that, reference method. transformed absorbance several pre-treatm...

Journal: :Science 2001
R A Dunn D R Toomey R S Detrick W S Wilcock

Tomographic images of upper mantle velocity structure beneath an overlapping spreading center (OSC) on the East Pacific Rise indicate that this ridge axis discontinuity is underlain by a continuous region of low P-wave velocities. The anomalous structure can be explained by an approximately 16-kilometer-wide region of high temperatures and melt fractions of a few percent by volume. Our results ...

Journal: :Journal of medicinal chemistry 2003
Jerald C Hinshaw Dae-Yeon Suh Philippe Garnier Frederick S Buckner Richard T Eastman Seiichi P T Matsuda Bridget M Joubert Isabelle Coppens Keith A Joiner Salim Merali Theodore E Nash Glenn D Prestwich

Small-molecule oxidosqualene cyclase (OSC) inhibitors were found to be effective in assays against cloned OSC-like enzymes from human pathogens. A combinatorial library was prepared and used to identify lead compounds that inhibit the growth of Trypanosoma cruzi, Leishmania mexicana amazonensis, and Pneumocystis carinii in culture. Selectivity for the microorganisms in preference to mammalian c...

2006
A. Mikhailichenko

A compact ring can be used to verify the OSC principles. Possible parameters of such ring described in this paper. INTRODUCTION After proposal to extend Stochastic Cooling method [1] to optical bandwidths [2], the idea about testing this method on specially designed compact damping ring was described soon after [3]. It was stressed there, [3], that under rates of cooling, deviled by OSC, the me...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Dawn E Telford Sara M Lipson P Hugh R Barrett Brian G Sutherland Jane Y Edwards Johannes D Aebi Henrietta Dehmlow Olivier H Morand Murray W Huff

OBJECTIVE Inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), an enzyme in the cholesterol synthesis pathway, has the unique ability to inhibit cholesterol synthesis while simultaneously enhancing oxysterol synthesis. Our objectives were to determine, in vivo, if a novel OSC inhibitor reduced low-density lipoprotein (LDL) cholesterol and to define the mechanism(s) involved. METHODS AND ...

2014
Sanne Lykke Lundstrøm Kasper Edwards Thomas Bøllingtoft Knudsen Pia Veldt Larsen Susanne Reventlow Jens Søndergaard

Background. Relational coordination (RC) and organisational social capital (OSC) are measures of novel aspects of an organisation's performance, which have not previously been analysed together, in general practice. Objectives. The aim of this study was to analyse the associations between RC and OSC, and characteristics of general practice. Methods. Questionnaire survey study comprising 2074 pr...

2015
Federica Maione Simonetta Oliaro-Bosso Claudia Meda Federica Di Nicolantonio Federico Bussolino Gianni Balliano Franca Viola Enrico Giraudo

Aberrant cholesterol homeostasis and biosynthesis has been observed in different tumour types. This paper investigates the role of the post-squalenic enzyme of cholesterol biosynthesis, oxidosqualene cyclase (OSC), in regulating tumour angiogenesis and metastasis dissemination in mouse models of cancer. We showed that Ro 48-8071, a selective inhibitor of OSC, reduced vascular density and increa...

2016
Christine L. Gray Brian W. Pence Lynne C. Messer Jan Ostermann Rachel A. Whetten Nathan M. Thielman Karen O’Donnell Kathryn Whetten

BACKGROUND Communities and nations seeking to foster social responsibility in their youth are interested in understanding factors that predict and promote youth involvement in public activities. Orphans and separated children (OSC) are a vulnerable population whose numbers are increasing, particularly in resource-poor settings. Understanding whether and how OSC are engaged in civic activities i...

Journal: :Blood 1981
R A Streuli J R Kanofsky R B Gunn S Yachnin

Oxygenated sterol compounds (OSC), when incubated for 1 hr with human erythrocytes in lipoprotein-depleted medium at concentrations of 0.625-5 X 10(-5) M, are inserted into the cell membrane and remain there despite subsequent washing of the cells. The insertion results in expansion of the surface area of the red cell ghost membrane, an increase in critical hemolytic volume, and as a consequenc...

Journal: :Child abuse & neglect 2012
Charles Glisson Philip Green Nathaniel J Williams

OBJECTIVE The study: (1) provides the first assessment of the a priori measurement model and psychometric properties of the Organizational Social Context (OSC) measurement system in a US nationwide probability sample of child welfare systems; (2) illustrates the use of the OSC in constructing norm-based organizational culture and climate profiles for child welfare systems; and (3) estimates the...

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