Semen analysis is the frontline and old reliable test in the assessment of male fertility, but it failed to provide absolute prediction of sperm function and its fertilizing ability. A wide variety of internal and external factors affect sperm function without discernible and significant effects on semen analysis. Oxygen toxicity and oxidative stress (OS) are inherent challenge of living cells ...

Introduction: Due to the anti-proliferative properties of platinum group-thiosemicarbazone complexes, the production of 191Os-labeled 2-acetyl pyridine 4-N-methylthiosemicarbazone (191Os-APMTS) was investigated. Methods: [191Osmium (T½= 15.4d) was produced via the 190Os(n,γ)191Os nuclear reaction using enriched target irradiated...

Osteosarcoma (OS) is the eighth common cancer of childhood and its incidence is 4 cases in one million in children younger than 14. Facial OS incidence is estimated between 8 and 10% of OS cases. The main etiology of OS is unknown, but various predisposing factors are proposed such as radiation, radiotherapy, some benign bone diseases like Paget’s disease or fibrous dysplasia. There is a 5-year...

BACKGROUND The prognostic value of the NIH consensus criteria for graft-versus-host disease (GVHD) is not well defined yet. PATIENTS AND METHODS We analyzed NIH-defined GVHD in 147 acute lymphoblastic leukemia (ALL) patients. RESULTS The cumulative incidence of classic acute GVHD (aGVHD), late aGVHD and chronic GVHD (cGVHD) was 63%, 12% and 41%, respectively. cGVHD was subclassified as clas...

Omenn syndrome (OS) is a rare primary immunodeficiency characterized by the presence of activated/oligoclonal T cells, eosinophilia, and the absence of circulating B cells. OS patients carry leaky mutations of recombination activating genes (RAG1 or RAG2) resulting in partial V(D)J recombination activity, whereas null mutations cause severe combined immunodeficiency with absence of mature T and...

Aksesuar kemikçikler ve sesamoid kemikler, ayakta çeşitli hastalıklara neden olan kırıkları taklit eden kemikleşmesini tamamlamış kemik yapılardır. Radyografilerde tesadüfen keşfedilirler çoğu zaman gözden kaçırılarak yanlış teşhislere yol açarlar. Bu nedenle, acil servise ayak bileği şikâyeti ile başvuran hastaların radyografi görüntülerinde aksesuar kemikçik kemiklerin görülme sıklığının beli...

Objective: We present a series of patients with flexor hallucis longus tenosynovitis submitted to hindfoot endoscopy, describing clinical outcomes and reporting surgical findings complications seen throughout the treatment. Methods: Thirty-one diagnosed posterior ankle endoscopy were followed. The mean follow-up was 24 months. Patients classified according American Orthopaedic Foot Ankle Societ...

Patients with Omenn syndrome (OS) have hypomorphic RAG mutations and develop varying manifestations of severe combined immunodeficiency. It is not known which symptoms are caused directly by the RAG mutations and which depend on other polymorphic genes. Our current understanding of OS is limited by the lack of an animal model. In the present study, we identified a C57BL/10 mouse with a spontane...

Acquired anomalies of the craniovertebral junction although rare, may result in serious clinical sequella. The prevalence of craniovertebral anomalies remains unknown since they may remain clinically silent. Os odontoideum is one such anomaly. The etiology remains controversial over whether it is a post-traumatic or congenital condition but the clinical considerations of os odontoideum remain t...