ORTHOTOPIC liver transplantation is frequently associated with hemostatic disorders and a bleeding diathesis.I.2 Accelerated fibrinolysis has been recognized as an important component of the hemostatic defectY The origin of this fibrinolytic activity, however, is still unclear. We investigated the role of tissue-type plasminogen activator (tPA). a potent activator of the fibrinolytic system, in...

Submit Manuscript | http://medcraveonline.com Abbreviations: CHLT: Combined heart and liver transplantation; FAP: Familial Amyloid Poly neuropathy; OLT: Orthotopic Liver Transplant; OHT: Orthotopic Heart Transplant; UNOS : United Network for Organ Sharing; OPTN: Organ Procurement and Transplantation Network; HLT: Heart-Liver Transplant; HRT: Heart Transplant; LIV: Liver Transplant; ECMO: Extrac...

Metastatic melanoma is a recalcitrant tumor. Although "targeted" and immune therapies have been highly touted, only relatively few patients have had durable responses. To overcome this problem, our laboratory has established the melanoma patient-derived orthotopic xenograft (PDOX) model with the use of surgical orthotopic implantation (SOI). Promising results have been obtained with regard to i...

Progress in immunosuppression, surgical techniques, and perioperative care has promoted orthotopic liver transplantation from an experimental procedure to an accepted clinical treatment. Orthotopic liver transplantation, in turn, has changed the treatment of terminal liver disease from care that is largely treatment of symptoms and support to cure, but at the price of major surgery and life-lon...

Two patients with situs inversus and biliary atresia were treated with hepatic transplantation, one with an auxiliary liver and the other with an orthotopic graft which was placed using a piggy-back technique. Both transplants functioned well initially. The auxiliary liver was rejected after 1 ~ months, and the patient died after an attempt at retransplantation many months later. The recipient ...

Background—The aim of this study was to derive and validate a risk score for rejection after orthotopic heart transplantation. Methods and Results—The United Network for Organ Sharing registry was used to identify patients undergoing orthotopic heart transplantation between 1998 and 2008. A total of 14 265 eligible patients were randomly divided into derivation (80%; n 11 412) and validation (2...

We reported previously a significant increase in survival of nude rats harboring orthotopic A549 human non-small cell lung cancer tumors after treatment with a combination of exisulind (Sulindac Sulfone) and docetaxel (D. C. Chan, Clin. Cancer Res., 8: 904-912, 2002). The purpose of the current study was to determine the biochemical mechanisms responsible for the increased survival by an analys...

PURPOSE Despite advances in our understanding, prevention, and treatment of head and neck squamous cell carcinoma (SCC), the 5-year survival rates for patients remain low. This poor prognosis for head and neck SCC and SCC of the oral tongue (SCCOT) in particular reflects a limited understanding of the mechanisms of local and regional metastasis, which accounts for a majority of deaths. To analy...

We describe a case of giant cavernous haemangioma of the liver with disseminated intravascular coagulopathy (Kasabach-Merritt syndrome) which was cured by orthotopic liver transplant. A 47 year old man presented with bleeding and tender massive hepatomegaly after tooth extraction. Investigations showed disseminated intravascular coagulopathy and a giant hepatic haemangioma involving both lobes ...

Received September 2009 Accepted February 2010 INTRODUCTION Radical cystectomy with urinary diversion is the standard treatment for muscle invasive bladder cancer.(1) The ileal conduit has long been considered as the gold standard for urinary diversion. Continent urinary diversion with orthotopic neo bladder offers distinct advantages over ileal conduit. Orthotopic ileal neo bladder provides la...