Objective: To examine patients’ experiences of taking orlistat and as a means to explore adherence and behaviour change. Method: Qualitative interviews with twelve participants who had taken orlistat in the past two years. Results: Their experiences were described in terms of beliefs about the causes of their obesity, their motivations for taking orlistat and the highly visual side effects. The...

BACKGROUND Orlistat is a lipase inhibitor which reduced absorption of dietary fat by ~30% thereby inducing a weight loss; however, side effects occur as a consequence of increased colonic fat content. To test the hypothesis that most gastrointestinal side events induced by treatment with orlistat could be prevented/ameliorated by concomitant use of natural dietary components, flaxseed fiber (FF...

Orlistat is an anti-obesity drug that inhibits the secretion of gastric and pancreatic lipases. Normally lipase breakdown triglyceride in intestine as a result metabolism. Despite numerous advantages this drug, researchers are facing problems with estimation by HPLC because limited methods available; only United State Pharmacopoeia (USP) method most reliable effective. The present work aimed to...

Weight management means lifestyle modification, behavioral therapy, pharmacotherapy and surgery. Drugs have wide ranging side effects and contraindication for its widespread use. Orlistat and sibutramine are the most popular in the present day context. Anti depressants especially fluoxetine is a valuable adjunct for therapy of obesity. There are many newer concepts in weight management and thes...

Obesity is an emerging risk factor for chronic kidney disease (CKD) in the developed world. Orlistat, an intestinal lipase inhibitor, used in the treatment of obesity is available as an over-the-counter medication across the European union and in many countries worldwide. It is associated with acute kidney injury (AKI). We present three adults, followed up from 1 to 6 years, who developed de no...

Introduction: The weight-loss drugs can induce depression. Orlistat is one of the common drugs, but preclinical studies about its effect on mood have not been performed. aim this study was evaluating orlistat alone and following inducing stress mice depressive behavior.
 Methods: In fundamental-applied study, male white (27±2 g), in six groups having 7 animals were used. administered orall...