This research was carried out to predict marital satisfaction based on parental marital satisfaction and healthy family-of-origin. In this study, martial satisfaction is considered as the most important component of marriage. This research had a descriptive, correlational design. The statistical population of the study included all young couples aged 30-40 in Kermanshah whose marriage had laste...

The packaging of eukaryotic DNA into nucleosomes is a critical regulator of nuclear events. To address the interplay between chromatin and replication initiation, we have assessed the determinants and function of the nucleosomal configuration of S. cerevisiae replication origins. Using in vitro and in vivo assays, we demonstrate that the yeast initiator, the origin recognition complex (ORC), is...

Whole-cell voltage-clamp experiments and single-channel current recordings in cell-attached patch mode were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to compare the characteristics of inward rectifier K' current (IK1) and delayed rectifier K' current (IK) between endocardial and epicard...

A s the periodic bloodshed continues in the Middle East, the search for an equitable solution must come to grips with the root cause of the conflict. The conventional wisdom is that, even if both sides are at fault, the Palestinians are irrational “terrorists” who have no point of view worth listening to. Our position, however, is that the Palestinians have a real greivance: their homeland for ...

When a program P fails to satisfy a requirement R supposedly ensured by a detailed speciication S that was used to implement P, there is a question about whether the problem arises in S or in P. We call this determination fault origin adjudication and illustrate its signiicance in various software engineering contexts. The primary contribution of this paper is a framework for formal fault origi...

The HMR-E silencer is a DNA element that directs the formation of silent chromatin at the HMRa locus in Saccharomyces cerevisiae. Sir1p is one of four Sir proteins required for silent chromatin formation at HMRa. Sir1p functions by binding the origin recognition complex (ORC), which binds to HMR-E, and recruiting the other Sir proteins (Sir2p to -4p). ORCs also bind to hundreds of nonsilencer p...

The assembly and disassembly of protein complexes at replication origins play a crucial role in the regulation of chromosomal DNA replication. The sequential binding of the origin recognition complex (ORC), Cdc6, and the minichromosome maintenance (MCM/P1) proteins produces a licensed replication origin. Before the initiation of replication can occur, each licensed origin must be acted upon by ...

â  multiple hepatic lesions and fever of unknown origin

The origin recognition complex (ORC) specifies replication origin location. The Saccharomyces cerevisiae ORC recognizes the ARS (autonomously replicating sequence) consensus sequence (ACS), but only a subset of potential genomic sites are bound, suggesting other chromosomal features influence ORC binding. Using high-throughput sequencing to map ORC binding and nucleosome positioning, we show th...