The outer hair cell (OHC) underlies mammalian cochlea amplification, and its lateral membrane motor, prestin, which drives the cell's mechanical activity, is modulated by intracellular chloride ions. We have previously described a native nonselective conductance (G(metL)) that influences OHC motor activity via Cl flux across the lateral membrane. Here we further investigate this conductance and...

In our previous studies, we have demonstrated that common cormorants (Phalacrocorax carbo) inhabiting Lake Biwa, Japan are contaminated with various chemicals, such as dioxins and related compounds (DRCs), organochlorines, organotins, brominated flame retardants, and perfluorinated compounds (PFCs). Since wild cormorants are exposed to these compounds simultaneously, mixture toxicities of them ...

Aeromonas molluscorum Av27 cells were exposed to 0, 5 and 50 μM of TBT and the respective transcriptomes were obtained by pyrosequencing. Gene Ontology revealed that exposure to 5 μM TBT results in a higher number of repressed genes in contrast with 50 μM of TBT, where the number of over-expressed genes is greater. At both TBT concentrations, higher variations in gene expression were found in t...

Marine organisms are affected by organotin compounds due to the cumulative, deleterious effects of these latter. The most evident and well known consequence of organotin contamination is imposex, a hormonal disruption that causes a superimposition of sexual male features in females of prosobranchia neogastropod molluscs such as Stramonita haemastoma floridana. Molluscs accumulate organotins mai...

Samples of blue mussel (Mytilus trossulus) and sediment were collected in the Gulf of Gdańsk (Southern Baltic Sea) to assess the extent of their contamination with two groups of endocrine disruptors: 4-nonylphenols and organotins (butyl- and phenyltins). Five sampling stations were chosen along the coastline of the Tricity Agglomeration (Gdańsk, Sopot, Gdynia) in 2008, 2012, and 2013. No eviden...

The heme-cytochrome P-450 complexes represent sensitive metabolic systems for examining the biological impact of metals on important cellular functions. Many metals, both in the inorganic form and bound to organic moieties, potently induce heme oxygenase, the rate limiting enzyme of heme degradation. The resulting increase in the rate of heme breakdown is reflected in a marked depression of cel...

After the United Nation’s International Maritime Organization banned the use of organotins in antifouling products, organic booster biocides were introduced as alternatives to these compounds. The purpose of this study was to measure concentrations of the antifouling agent Irgarol 1051, its major metabolite M1 (aka GS26575), and other antifouling pesticides (diuron, chlorothalonil, dichlofluani...

BACKGROUND The use of alternative flame retardants has increased since the phase out of pentabromodiphenyl ethers (pentaBDEs). One alternative, Firemaster® 550 (FM550), induces obesity in rats. Triphenyl phosphate (TPP), a component of FM550, has a structure similar to that of organotins, which are obesogenic in rodents. OBJECTIVES We tested the hypothesis that components of FM550 are biologi...