The epithelial cells that line the renal proximal tubule have been shown to be the primary cellular targets where mercuric ions gain entry, accumulate, and induce pathologic effects in vivo. Recent data have implicated at least one of the organic anion transport systems in the basolateral uptake of inorganic mercury (Hg). With the use of a line of type II MDCK cells transfected stably with the ...

A robust screen for compound interaction with P-glycoprotein (P-gp) has some obvious requirements, such as a cell line expressing P-gp and a probe substrate that is transported solely by P-gp and passive permeability. It is actually difficult to prove that a particular probe substrate interacts only with P-gp in the chosen cell line. Using a confluent monolayer of MDCKII-hMDR1 cells, we have de...

The use of ceramic low pressure membranes for drinking water production has been increasing in the past decades. However, fouling during membrane operations is still a challenging topic that requires attention and investigation. During filtration of surface water, a major contribution to fouling is attributed to the presence of dissolved organic carbon(DOC) and its fractions which comprise biop...

where SOC is the surface organic content; R, G, and B are image intensity values in the red, blue and green Past research has attempted to relate surface characteristics of soils bands, respectively; and a, b, c and d are curve-fit paramto reflectance from remotely sensed images to provide a means for quantifying spatial heterogeneity. Existing procedures have proven eters. The Chen et al. (200...

Two Aerodyne Aerosol Mass Spectrometers (AMS) were deployed at three sites representing urban, semi-rural and rural areas during the Pacific 2001 experiment in the Lower Fraser Valley (LFV), British Columbia, Canada in August 2001. The AMS provides on-line quantitative measurements of the size and chemical composition of the non-refractory fraction of submicron aerosol particles. A significant ...

We investigate whether beer drinkers are willing to pay a price premium for organic beer compared to conventional beer. Moreover, we identify subgroups of consumers with different preference patterns by investigating whether specific personal characteristics of the purchasers have an influence on this willingness-to-pay. Specifically, results are reported from a survey including a stated choice...

In the beginning, Eiichi was the latest in a striking line of ingenious Japanese organic chemists. In their hands, meticulous attention to detail in the tuning of reagents and conditions has given the community a cornucopia of reliable synthetic procedures of great utility. A substantial segment of the name reactions of the second half of the 20th century are Japanese; the 2010 Nobel Prize in C...

This work reports on the hysteresis behavior and an initial baseline drift of printed strain gauges embedded in organic coating layers on sheet steel that we recently introduced. We subsequently investigated the performance over an extended period of time, which revealed interesting and partially unexpected material properties of printed strain gauges made from silver and carbon. Both silverand...