Topiramate [2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate] is a structurally novel antiepileptic drug that has broad efficacy in epilepsy, but the mechanisms underlying its therapeutic activity are not fully understood. We have found that topiramate selectively inhibits GluK1 (GluR5) kainate receptor-mediated excitatory postsynaptic responses in rat basolateral amygdala (BL...

صلاخلا ــ ة : مت ةقرولا هذه يف ءاشنإ يف هدعاسملل مدقتم ماظن بناوج ذيفنتو ميمصت ضرع قتو و مي ءادأ حيحصت تارفش لأا ءاطخ ةليلق لا ةناتم ، ةينبم ىلع ءوفاكتلا رايتخا . موقي امه نيتيسيئر نيتفيظوب ةساردلا هذه يف مدقتملا ماظنلا : 1 ادأ باسحل ةيزاوتملا هاآاحملا ء تارفش حيحصت لأا ءاطخ ةليلق نمزب ةفاثكلا ادج ريصق ةنراقم ةمظنأب ةاآاحملا ةدوجوملا . 2 ةليلق ءاطخلأا حيحصت تارفشو فعضلا قطانم صحف نع ة...

Abstract This commentary sheds light on the integration of cascading environmental, economic, and social risks into conscious sustainable development strategies. For this, we investigated Andean Trade Preference Act (ATPA), which was established in 1991 to simultaneously fight against production, processing, trafficking illegal drugs while also developing alternative industries expand economic ...

Introduction While accessing the posterior fossa, anterior transpetrosal approach (ATPA) and endoscopic transorbital (ETOA) use same bony landmarks during petrous apex drilling. However, owing to their contrasting surgical axes, they are expected show differences in view, maneuverability, clinical implications. This study aimed investigate feasibility of ETOA brainstem compare view maneuverabil...

Bifidobacterium animalis, one of the predominant bacteria in intestines humans and other mammals, is widely added to dairy products. We employed RNA sequencing analyze gene expression variance on a genome-wide scale found stable reference genes (RG) B. animalis. A total 1,665 were identified by analyzing data from transcriptome under 4 different conditions, 13 probable candidate RG with variati...

Transcription from modified chloroplast genes has been studied in vitro, but only with the recently developed ability to stably introduce foreign DNA into Chlamydomonas reinhardtii chloroplast chromosomes in situ has it become possible to do so in vivo. Cloned chloroplast DNA sequences, into which had been inserted chimeric genes composed of the GUS coding sequence reporter under transcriptiona...

Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and hippocampus, which are relevant to seizures and epilepsy. Here we used 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in conjunction with...

صخلملا Seasonal variation of zooplankton biomass has been carried out at two selected sites on Greater Zab River. Monthly samples of water were collected during period from January to December 2008. Some physico-chemical properties of water were studied including water temperature (from 8 to 30.5 C), hydrogen ion concentration (from 6.3 to 8), EC (from 255 to 821 μs.cm), turbidity (1085 NTU), d...

The reaction of cobalt(II) nitrate with 5-amino-2,4,6-tri-iodo-isophthalic acid (ATPA) in pyridine solution leads to the formation of the title compound, {[Co(C(8)H(2)I(3)NO(4))(C(5)H(5)N)(3)(H(2)O)]·C(5)H(5)N}(n). The Co(2+) ion is six-coordinated by three N atoms, one water O atom and two O atoms from two ATPA ligands to form a distorted octa-hedral geometry. The two carboxyl-ate groups of AT...

خلا صلا ـ ة : عون نم يفيكتلا ةانقلا ردقم ءادلأ اًضرع ثحبلا اذه مدقي LMS ةيئاضفلا ةرفشملا تاعومجملا مظن يف نييئاوه مدختست يتلا ةينمزلا لإل اسر ل لابقتسلال اًدحاو اًيئاوهو . و ةانق يه ةمدختسملا ةيكلسلالا ةانقلا Rayleigh ءاضوضلا دوجوب ىسواجلا (Gaussian) يمجتلا جارخلاا يف يع . و حضوت ثحبلا جئاتن إ دحاو لماعم يذ ةانق ردقم مادختساب زاحنم ريغ ريدقت ىلع لوصحلا ةيناكم ) يراسم نم لكل لإا ةراش .( و وحن ةيف...