BACKGROUND Surgery remains the first choice of treatment for tongue cancer. Immediate reconstruction should be performed after wide resection of tumour. The aim of this study was to evaluate the anterolateral thigh flap for reconstruction of lingual defects. METHODS We report 39 consecutive oral tongue squamous cell carcinoma patients who underwent lingual reconstruction with the anterolatera...

Introduction: Individual oral stent is a mouth-opening device that used in head and neck cancer radiotherapy with the intention of decreasing radiation dose to health tissues. The aim of this study was to check the dose delivered to both the hard palate and tongue when patient uses the stent during radiotherapy of tongue carcinoma. Methods and materials<stron...

In xeroderma pigmentosum, a rare genodermatosis, transmitted as an autosomal recessive disorder, excessive solar damage to the skin develops at an early age. The disease is characterized by cutaneous, ocular, neurological and oral changes. Oral features in the form of early development of squamous cell carcinoma, usually at the lower lip and tip of the tongue may be seen. The disorder is associ...

Oral cancer is the sixth common tumour worldwide [1]. Oral cancer is the fourth leading cause of cancer death for males [2]. Oral squamous cell carcinoma (OSCC) is the most common neoplasia and is found frequently in oral cavity in the cheek, gingiva and tongue [3]. Although cigarette and alcohol are considered as two major etiological factors of oral carcinogenesis [4], occurrence of oral canc...

Whether Slit homologue 2 (Slit2) inhibits or promotes tumor cell migration remains controversial, and the role of Slit2‑Roundabout 1 (Robo1) signaling in oral cancer remains to be fully elucidated. The aim of the present study was to investigate the role of Slit2‑Robo1 signaling in the adhesion, invasion and migration of tongue carcinoma cells, and the mechanism by which Slit2‑Robo1 signaling i...

We demonstrate a rare case of lingual thyroid together with squamous cell carcinoma of the base of tongue. 54-year-old patient presented with left sided lymph node enlargement in regions II, III and IV without any clinical symptoms. Physical examination revealed semicircular bulge at the base of tongue measuring 30 x 20 mm and tumorous lesion was suspected. Neck ultrasound showed pathological e...

BACKGROUND Abnormalities of PTEN, a candidate tumor suppressor gene located at 10q23.3, play an important role in the tumorigenesis of multiple tumor types. OBJECTIVES To investigate the expression of PTEN and its clinical implication in squamous cell carcinoma of the tongue. DESIGN Retrospective analysis of PTEN protein expression in archived primary oral tongue tumor samples. SETTING Ac...

Aim: To determine the Frequency and Pattern of Presentation Oral Squamous Cell Carcinoma its Predisposing Factors in Patients Presented to Nishtar Institute Dentistry. Study design: Cross sectional study. Place Duration Study: was conducted from Aug 2021 Jan 2022 at Methodology: A total 100 patients were included. aged between18-80 years males females included whom presented with oral squamous ...

Squamous cell carcinoma and its histologic variants account for over 90% of all malignancies of the oral cavity. Early squamous cell carcinoma often presents as a white lesion (leukoplakia), red lesion (erythroplakia), or a combination of both (erythroleukoplakia). 1,2,3,4 However, with time, superficial ulceration of the mucosal surface may develop. As the lesion grows, it may become an exophy...

Oral squamous cell carcinoma has high chances of cervical lymph node metastasis. This case series describes the distribution of cervical lymph nodes in 50 cases of squamous cell carcinoma of tongue and floor of mouth. The mean age was 47.28±10.5 years. Thirty positive metastatic lymph nodes were found; 90% occurring at level I-II mostly in T4 size but also in T1 and T2 cases. The distribution o...