abstract background: iron overload is a clinical consequence of repeated blood transfusions and causes significant organ damage, morbidity, and mortality in the absence of proper treatment. the primary targets of iron chelators used for treating transfusional iron overload are the prevention of iron ingress into tissues and its intracellular scavenging. the present study was aimed at elucidatin...

1. Díez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148:293-300. 2. Leth H, Andersen KK, Frystyk J, Tarnow L, Rossing P, Paeving HH, et al. Elevated levels of high-molecularweight adiponectin in type 1 diabetes. J Clin Endocrinol Metab. 2008;93:3186-91. 3. Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Dia...

this work reports a facile sonochemical route in the synthesis of nano particle of deferasirox for the first time. one application of nanotechnology is in improvement of available treatments for various diseases. deferasirox (icl670 or exjade) is a tridentate chelating agent for removing transfusion overload iron in thalassemia patients. in the present work, deferasirox was prepared in nano size...

This study details the prevention of gentamicin-induced hearing loss in guinea pig in vivo. The approach is based on our recent demonstrations of a redox-active gentamicin-iron complex in vitro and partial attenuation of gentamicin-induced hearing loss by the iron chelators deferoxamine and 2,3-dihydroxybenzoate. In our study, guinea pigs receiving injections of gentamicin (120 mg/kg body weigh...

In view of the profound functional and structural abnormalities shown in our previous studies in cultured, iron-loaded rat heart cells, we have examined the ability of the orally effective iron chelators dimethyl-3-hydroxypyrid-4-one (DMHP or L1) and diethyl-3-hydroxy-pyrid-4-one (DEHP or CP94) and of deferoxamine (DF) to reverse the damage caused by iron loading to heart cell organelles. At a ...

The combined addition of reduced form of glutathione (GSH) and iron chelators for decrease of the intracellular level of reactive oxygen species (ROSs) and death of Chinese hamster ovary (CHO) cells was investigated. The addition of GSH to the serum-free cultures of CHO cells markedly lowered the intracellular ROS level, which effect was comparable to that of the addition of serum (0.4, 10%) an...

hydroxypyridinone iron chelators are currently the main candidates for development of orally active iron chelating alternatives to desferrioxamine (dfo). in the present study, the relative efficacy and liver toxicity of a bidentate chelator, 2-methyl-3-hydroxypyridin-4-one (mhpo), was studied in iron overloaded rats and compared with those of dfo. for iron overloading, rats received i.p. inject...