This paper discusses extracorporeal removal of viral particles and their antigens from the blood as an auxiliary therapy. This hypothesis has not been reported before. In some chronic blood-borne viral infections, the virus remains systemic and persistent for extended periods of time, with adverse effects that weaken the immune system. Blood titers of virus and its toxins are proportional to th...

The synthesis of the title compound, bitamycin, by means of BU4NF is described. This new antiviral drug was found to be one of the most powerful and least toxic substances for antiviral therapy in man. The physical and chemical behavior as well as the antiviral activities and clinical properties of this compound were found to be significantly different from that reported by Schaeffer, et a...

Etravirine is an oral diarylpyrimidine compound, a second-generation human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitor (NNRTI) with expanded antiviral activity against NNRTI-resistant HIV-1, to be used in combination therapy for treatment-experienced patients. Compared with first-generation NNRTIs, etravirine has a high genetic barrier to resistance, and...

lichen planus is a chronic inflammatory mucocutaneous disease. mucosal lesions are classified into six clinical forms and there is malignant potential for two forms of olp; therefore, follow-up should be considered. there are many un-established etiological factors for olp and some different treatment modalities are based on etiology. the aims of current olp therapy are to eliminate mucosal ery...

BACKGROUND & AIMS Hepatitis C (HCV) is a common cause of chronic liver disease worldwide. Current standard treatment for genotype-1 patients uses a triple combination of pegylated-interferon alpha (IFN), ribavirin (RBV) and a direct-acting antiviral agent (DAA) with 75-80% sustained virologic response (SVR) rates. The aim is to determine cost-effectiveness of staging-guided vs. treat all HCV ge...

conclusions further studies on the role of hepcidin in pathogenesis of chc are needed to assess the potency of its use in antiviral treatment. results patients with chc had lower hepcidin mrna expression and more frequently iron deposits in hepatocytes than subjects with chb did. in chc group, hepcidin mrna expression was positively correlated with alanine aminotransferase activity and serum ir...

BACKGROUND Type 2 diabetes is a well described extra-hepatic manifestation of hepatitis C infection (HCV). Eradication of HCV has led to improvements in insulin resistance but to date has not been shown to induce remission of diabetes. CASE REPORT We report a case of a 49-year-old man with HCV and a 2-year history of T2DM on oral agents. He was initially treated with peg-interferon/ribavirin ...

Hepatitis B is the most common cause of chronic viral hepatitis in the world, and an estimated 257 million people are living with a current hepatitis B virus (HBV) infection, which is defined as being HBsAg positive. In 2015, 887,000 deaths were due to hepatitis B, mostly from complications such as cirrhosis and hepatocellular carcinoma. The initial antiviral therapy for chronic hepatitis B (CH...

The immune responses (serum anti-porcine epidemic diarrhea virus [PEDV] immunoglobulin G [IgG] and milk antiviral neutralizing antibodies) induced by various combinations of two PEDV immunization modalities (vaccine and oral immunization) were examined in unrelated swine production units in different locations. Anti-PEDV antibodies were undetectable in serum and milk of the control group (non-v...