a study was conducted to investigate the effect of different planting densities and nitrogen doses on essential oil content and yield in herb and leaves of basil (ocimum basilicum l.). the research was conducted during 2007 and 2008 using split-plot randomized complete block design with four replications. the experiment consisted of four plant densities (30×20, 40×20 and 50×20 cm) as the main p...

The aim of the present study was to describe the pharmacokinetics of caspofungin in 12 critically ill adult patients with suspected or proven invasive candidiasis who were receiving continuous venovenous hemodiafiltration (CVVHD). CVVHD was performed using a polysulfone hemofilter (Fresenius, Germany). Caspofungin was administered at usual doses. Pre-filter and post-filter blood, ultradiafiltra...

Page 287 Successful Treatment of Schizophrenia Requires Optimal Daily Doses of Vitamin B3 For over 50 years Dr. Abram Hoffer has been educating clinicians about the need to correctly (optimally) dose schizophrenics with vitamin B3 (niacin; niacinamide). For the past 10 years I have, likewise, educated numerous naturopathic and medical doctors about the very same thing. For some reason, both typ...

The distribution of surface IgE on human basophils was studied using fluorescence microscopy and immunoferritin electronmicroscopy. Redistribution of the IgE was dose, time and temperature dependent and required divalent anti-IgE. Cells which can release histamine in vitro were indistinguishable in these respects from cells which cannot. The redistribution was unaffected by the presence or abse...

was found between digoxin dosage and plasma digoxin concentration. Patients who did not develop symptoms of digitalis intoxication until at high doses showed a slower increase ofplasma levels. At the first appearance of toxic symptoms 'steady state' values of about 6 ng digoxin/ml werefound. Excluding one divergent patient, a close inverse correlation wasfound between plasma digoxin concentrati...

Expansion of CH2THF pools in tissues of BALB/c mice bearing s.c.-implanted EMT6 mammary adenocarcinomas was measured after leucovorin administration. Twenty-four mice were treated with leucovorin at doses of 0, 45, 90, or 180 mg/kg/injection x 8 injections spaced over 48 h. Tumor and bone marrow cytosols were assayed for CH2THF by forming ternary complexes with thymidylate synthase and [3H]FdUM...

PURPOSE To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo. METHODS Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial lon- gitudinal incision was made and infected with different bacteria. RESULTS It is showed that 0.5 mg/kg/time of LPS p...

Salbutamol solution is usually administered by nebuliser in a dose of 5 mg. Little evidence exists that this is the optimal dose for bronchodilatation or that this dose is without side-effects. Twelve patients with asthma were given increasing doses of salbutamol 1.5 mg, 3.0 mg, 7.5 mg, and placebo. Treatments were administered twice daily for four days in a double-blind manner. Measurements of...

tration. Safety and tolerance to KRN 860l were confirrned and a dose-related increase of neutrophil counts by KRN 8601 was observed. In an early phase II study, the safety and tolerance to KRN 8601 in cases of neutropenia following canceT chemotherapy were shown at doses of 25-800 "glm2 and an improvement of neutropenia was seen at doses of more than 50 "g/m2. . In a phase II study, the optimal...