Sulfur functions in position 8 of the flavin nucleus give rise to new modified flavin derivatives, which should prove useful as probes of the flavin binding domains of flavoproteins. Here, we report on some properties of 8-nor-8-alkylmercaptoflavins and 8-nor-8-mercaptoflavin which are readily formed by nucleophilic displacement by alkylmercaptides or sulfide, with 8-nor-8-chloroflavins as star...

The article examines the tensions involved in the development of treatment for mental disorders during the period 1950-1980 in the United States. It relates those tensions to the diffusion of a social ideal strongly influenced by the subjectivist fervor characteristic of post-war America but also internally contradictory. Psychiatric diagnosis came to be seen as a way of disqualifying the indiv...

Fungal nitric oxide reductase (cytochrome P450 nor) is a heme-containing enzyme, in which the iron-porphyrin complex is an active site of the enzyme. This enzyme is involved in the fungal denitrification process, and catalyzes the reduction of NO to N2O. Its structural and functional characteristics were examined by enzymatic, kinetic, spectroscopic (optical absorption, ESR, resonance Raman, IR...

The recurrent nova IM Nor was observed twice in X-rays with Chandra ACISS, 1 and 6 months after the optical outburst. It was not detected in the first

An external-cavity diode laser is reported with ultralow noise, high power coupled to a fiber, and fast tunability. These characteristics enable the generation of an optical frequency comb in a silica micro-resonator with a single-soliton state. Neither an optical modulator nor an amplifier was used in the experiment. This demonstration greatly simplifies the soliton generation setup and repres...

We report that the classical phenomenon of optical activity, which is traditionally associated with chirality (helicity) of organic molecules, proteins, and inorganic structures, can be observed in artificial planar media which exhibit neither 3D nor 2D chirality. We observe the effect in the microwave and optical parts of the spectrum at oblique incidence to regular arrays of nonchiral subwave...