The effect of increasing temporal frequency on contrast sensitivity anomalies in unilateral optic neuritis has been investigated. For 4 c/deg gratings no change in the deficit was observed at any temporal frequency whereas there was a tendency for the deficit to decrease with increase in temporal frequency for 0-5 c/deg gratings. The latter effect was not observed in a case of optic neuritis wi...

introduction: multiple sclerosis (ms) is a chronic, autoimmune, and inflammatory nervous system disease. it leads to the loss of myelin in the white matter of brain, spinal cord and optic nerves. as a chronic disease with sudden and unpredictable side effects and complications of the disease will lead to disability and dependency in life. causes neurologic symptoms and sig. the purpose of the p...

Demyelination is assumed to be the cause of the majority of cases of isolated optic neuritis. Because of the importance of establishing the presence of optic nerve dysfunction in patients suspected of having multiple sclerosis several new indices of optic nerve conduction have been reported including the visual evoked potential, the edge-light pupil cycle time, and the Pulfrich test. These meas...

PURPOSE To analyze in vivo the diffusion tensor magnetic resonance imaging (DT-MRI) properties of the intraorbital optic nerve at two different levels: Proximal to the optic nerve head (ONH) and distal to the ONH at the level of the orbital apex in glaucoma patients. METHODS Twenty-four patients with primary open-angle glaucoma were examined. The categorization into early and severe glaucoma ...

OBJECTIVE To determine if panretinal photocoagulation (PRP) alters retinal nerve fiber layer (RNFL) thickness and optic nerve appearance. METHODS Patients with diabetes who did and did not undergo PRP and nondiabetic control subjects were enrolled in a prospective study. Participants underwent optical coherence tomography of the peripapillary retina and optic nerve. Stereoscopic optic nerve p...

In 1970, based on my experimental and clinical studies, I defined glaucoma as: “a disease wherein the normal balance between the intraocular pressure and the blood pressure in the choroidal vessels supplying the optic disc and retrolaminar part of the optic nerve is disturbed, resulting in vascular insufficiency in the optic disc and retrolaminar part of the optic nerve, and hence in visual fie...

BACKGROUND Retinoblastomas are the most common malignant intraocular tumor of childhood. We describe the survival outcomes and prognostic factors of patients with a retinoblastoma receiving primary treatment at our hospital over the last 20 years. METHODS A retrospective series study of 30 retinoblastoma cases treated from January 1, 1987 to August 31, 2006 was conducted from a review of medi...

5 1) Introduction Glaucoma is a multifactorial neurodegenerative disorder characterized by progressive structural and functional injury of the optic nerve complex (optic nerve + parapapillary region) for which intraocular pressure (IOP) remains the only proven modifiable risk factor. Assessments of both structure and function of the optic nerve are indispensible aspects of the glaucoma examinat...

BACKGROUND Optical coherence tomography (OCT) has become an important tool for diagnosing optic nerve disease. The structural details and reproducibility of OCT continues to improve with further advances in technology. However, artifacts and misinterpretation of OCT can lead to clinical misdiagnosis of diseases if they go unrecognized. EVIDENCE ACQUISITION A literature review using PubMed com...

Non-arteritic anterior ischaemic optic neuropathy (NAION) is a widespread visually disabling disease in the middleaged and elderly population. Based on clinical observations by Hayreh, Beck, Savino and others, a low cup/disc diameter ratio and a small optic disc have been described to be structural factors associated with the disease. The physiological correlation between disc size and cup/disc...