Optic nerve sheath diameter enlargement measured by ultrasound is known to be associated with raised intracranial pressure (ICP). Magnetic resonance imaging (MRI) of the cerebrospinal fluid (CSF) surrounding the optic nerve has been found, in an elegant study published in Critical Care, to correlate well with lumbar CSF opening pressure, confirming previously published studies. A simple and rap...

BACKGROUND Research into retinal ganglion cell (RGC) degeneration and neuroprotection after optic nerve injury has received considerable attention and the establishment of simple and effective animal models is of critical importance for future progress. METHODOLOGY/PRINCIPAL FINDINGS In the present study, the optic nerves of Wistar rats were semi-transected selectively with a novel optic nerv...

We report that the most common retinal ganglion cell type that remains after optic nerve transection is the M1 melanopsin ganglion cell. M1 ganglion cells are members of the intrinsically photosensitive retinal ganglion cell population that mediates non-image-forming vision, comprising ∼2.5% of all ganglion cells in the rat retina. In the present study, M1 ganglion cells comprised 1.7±1%, 28±14...

purpose: to describe the association between optic disc traction and non-arteritic anterior ischemic optic neuropathy (naion). methods: eighty three eyes of 83 patients with naion were evaluated by optical coherence tomography (oct) for detecting vitreous adhesion to the optic nerve head with separation from adjacent retina (partial posterior vitreous detachment). those who were negative for su...

Stem cells are undifferentiated cells that have the ability to convert to different types of cells and after dividing, they can produce their own cells or other cells. Axons of the retinal ganglion cells, from the optic nerve. These cells lose the ability to regenerate themselves before birth. Optic nerve degeneration can result from various causes including increased intraocular pressure, comp...

a 15- year-old boy with history of bb gun injury to his left eye was referred to our center. his visual acuity was no light perception in the left eye. ocular findings were severe proptosis, conjunctival injection, and conjunctival vascular tortuosity. fundus examination revealed an extensive inferior chorioretinal scar compatible with chorioretinitis sclopetaria. a distinct bruit was detected ...

G laucoma is a disease characterised by apoptotic ganglion cell death related, at least in part, to intraocular pressure. Any examination for glaucoma must therefore include some comment upon the health of these cells. Unfortunately, it is difficult to examine the ganglion cell layer ophthalmoscopically and so ophthalmologists typically rely on an analysis of a more visible ocular structure—the...