Regulated intramembrane proteolysis is a method for transducing signals between cellular compartments. When protein folding is compromised in the periplasm of E. coli, the C termini of outer-membrane proteins (OMPs) bind to the PDZ domains of the trimeric DegS protease and activate cleavage of RseA, a transmembrane transcriptional regulator. We show here that DegS is an allosteric enzyme. OMP b...

background: colibacillosis is one of the most prevalentdiseases in the world that causes multimillion-dollar annuallosses. objectives: in order to evaluate molecular epidemiologyof some virulence associated factors in escherichia coli,isolated from poultry, the presence of iut a, iss, hly f, omp t, iron, afa, sfa (s)and pap g (ii) were investigated by multiplex pcrassay. methods: two hundred th...

BACKGROUND Various techniques have been developed to enable preceptors to teach residents effectively in outpatient settings to promote active learning, including SNAPPS and the One-Minute Preceptor (OMP). This study aimed to ascertain the differences between SNAPPS and the OMP in case presentation content and learner evaluation when used to teach residents about case presentation. METHODS Fr...

PURPOSE Porins are outer membrane protein (OMP) that form water filled channels that permit the diffusion of small hydrophilic solutes like beta-lactam antibiotics across the outer membrane. Two major porins that facilitate diffusion of antimicrobials have been described in Klebsiella spp. and Escherichia coli. The present study was carried out to examine the role of porins among Extended Spect...

In the context of torpedo guidance systems, performance active sonar in channel parameter estimation and target detection recognition is significantly degraded by multipath effect time-varying characteristics underwater acoustic (UWA) channel. Therefore, it urgent to propose an algorithm that can accurately estimate parameters UWA channels. To solve these problems, this study developed a modifi...

INTRODUCTION This study involved 300 Pseudomonas aeruginosa strains isolated from patients admitted in four Tehran hospitals. Using standard O-specific typing sera, they were all grouped into 16 strains out of 17 known P. aeruginosa. The strains were lyophilized and each was given a code according to the Collection of Standard Bacteria, Pasteur Institute of Iran (CSBPI) for further investigatio...

Ehrlichia chaffeensis, an obligatory intracellular gram-negative bacterium, must take up various nutrients and metabolic compounds because it lacks many genes involved in metabolism. Nutrient uptake by a gram-negative bacterium occurs primarily through pores or channels in the bacterial outer membrane. Here we demonstrate that isolated E. chaffeensis outer membranes have porin activities, as de...

OBJECTIVE To study the frequency of isolation of potential pathogens and interfering bacteria in the posterior nasopharynx of otitis media-prone (OMP) children and their smoking and nonsmoking parents to possibly explain why active and passive exposure to smoking is associated with carriage of potentially pathogenic bacteria and an increased risk of respiratory tract infection in both adults an...

Long QT syndrome is an arrhythmogenic disease characterized by prolonged interval. Citalopram (CIT) was reported to prolong interval dose-dependently. Omeprazole (OMP), inhibits CIT metabolizing enzyme CYP2C19, thereby increases serum concentrations which may increase the risk of prolongation. These are commonly co-prescribed and recent studies have raised safety concerns about. We aimed invest...

P2HP is a Peer-to-Peer (P2P)-based high performance distributed computing (HPDC) platform. Since the programming model is critical to HPDC systems, this paper focuses on the design and implementation of OMP, a One-sided Message Passing programming model for P2HP, which presents a general way to design the programming model for HPDC systems and shows that P2HP is a practical and efficient HPDC p...