PTEN induced kinase 1 (PINK1) is a serine/threonine kinase in the outer membrane of mitochondria (OMM), and known as a responsible gene of Parkinson's disease (PD). The precursor of PINK1 is synthesized in the cytosol and then imported into the mitochondria via the translocase of the OMM (TOM) complex. However, a large part of PINK1 import mechanism remains unclear. In this study, we examined u...

Mathematics is a fast growing discipline where an average of 120 thousand papers are published per year. We seek to provide better interfaces to interact with this huge collection of documents. To study new techniques that allow users to intuitively assess and interact with mathematical publication collections we use OpenMathMap (OMM) – a computer-generated map which represents Mathematical Sub...

Single-bout focused-attention meditation (FAM) and open-monitoring (OMM) are assumed to bias metacontrol states towards more persistent versus flexible processing, respectively. In Experiment 1, we tested whether monitoring updating of working memory (WM) representations in an N-back task with high (3-back), medium (2-back), low (1-back) WM demands (varied within participants) is affected by pr...

Little empirical work has been done to examine how osteopathic medical students' attitudes toward osteopathic principles and practice (OPP) develop and evolve over the course of their medical education. A major obstacle to conducting this research is the absence of reliable and sensitive instruments to measure students' attitudes toward OPP. The purpose of this project is to develop a sensitive...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 1 109–123 www.jcb.org/cgi/doi/10.1083/jcb.201404050 JCB 109 Correspondence to Mariusz Karbowski: [email protected] Abbreviations used in this paper: AvDev, average deviation; IMM, inner mitochondrial membrane; MEF, mouse embryonic fibroblast; Mff, mitochondrial fission factor; mito-PAGFP, mitochondrial matrix–targeted pho...

The cholesterol transfer function of steroidogenic acute regulatory protein (StAR) is uniquely integrated into adrenal cells, with mRNA translation and protein kinase A (PKA) phosphorylation occurring at the mitochondrial outer membrane (OMM). The StAR C-terminal cholesterol-binding domain (CBD) initiates mitochondrial intermembrane contacts to rapidly direct cholesterol to Cyp11a1 in the inner...

BACKGROUND Chronic radicular pain can be effectively treated with spinal cord stimulation, but this therapy is not always sufficient for chronic back pain. Subcutaneous nerve stimulation (SQS) refers to the placement of percutaneous leads in the subcutaneous tissue within the area of pain. Case series data show that failed back surgery syndrome (FBSS) patients experience clinically important le...

To the Editor: I read with great interest the case report in the December 2009 issue of JAOA— The Journal of the American Osteopathic Association by John M. Lavelle, DO, and Mark E. McKeigue, DO,1 regarding osteopathic manipulative treatment (OMT) of a patient with drop foot. Lavelle and McKeigue1 reported that a single 15-minute OMT session resolved their patient’s symptoms. I have had extensi...

Abstract Background Heart failure with reduced ejection fraction (HFrEF) is the global public health burden a prevalence of 1% adults. The current guidelines suggest use angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), beta-blockers (BB), mineralocorticoid antagonists (MRA), receptor-neprilysin (ARNIs), and sodium-glucose cotransporter-2 (SGLT2i) to reduce m...

Primary CD4(+) T lymphocytes, supporting in vitro human immunodeficiency virus type 1 (HIV-1) replication, are destined to die by apoptosis. We explored the initial molecular events that act upstream from mitochondrial dysfunction in CD4(+) T lymphocytes exposed to the HIV-1(LAI) strain. We tracked by immunofluorescence the cells expressing the p24 viral antigen and used Percoll density gradien...