Olfactory ensheathing cells (OECs) represent an interesting candidate for cell therapy and could be obtained from olfactory mucosa (OM-OECs) or olfactory bulbs (OB-OECs). Recent reports suggest that, depending on their origin, OECs display different functional properties. We show here the complementary and additive effects of co-transplanting OM-OECs and OB-OECs after lesion of a peripheral ner...

Deafferentation of the vomeronasal system by cutting the vomeronasal nelves severely impaired mating behavior in 44 ~ of male hamsters over a 1-2 month period of postoperative testing, but the remaining males mated normally after the surgery. Damage to the main olfactory bulbs, concomitant to vomeronasal nerve cuts, did not account for this behavioral difference. Subsequent deafferentation of t...

We used immunodeficient mice, whose dorsomedial olfactory region was permanently damaged by dichlobenil inoculation, to test the neuroregenerative properties of transplanted human adipose tissue-derived stem cells after 30 and 60 days. Analysis of polymerase chain reaction bands revealed that stem cells preferentially engrafted in the lesioned olfactory epithelium compared with undamaged mucosa...

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We demonstrated recently that transplantation of olfactory ensheathing cells from the nasal olfactory mucosa can promote axonal regeneration after complete transection of the spinal cord in adult rat. Ten weeks after transection and transplantation there was significant recovery of locomotor behaviour and restoration of descending inhibition of spinal cord reflexes, accompanied by growth of axo...

In a previous study (Le Gros Clark and Warwick, 1946) the degeneration of olfactory receptors in the rabbit following complete or partial ablation of the olfactory bulb was examined by reference to sections of the mucosa covering the septal cartilage, stained by Bodian's protargol method. Evidence was advanced to show that this is a true secondary degeneration following interruption of the prim...

A large set of xenobiotic-metabolizing enzymes (XMEs), such as the cytochrome P450 monooxygenases (CYPs), esterases and transferases, are highly expressed in mammalian olfactory mucosa (OM). These enzymes are known to catalyze the biotransformation of exogenous compounds to facilitate elimination. However, the functions of these enzymes in the olfactory epithelium are not clearly understood. In...

This first comprehensive study of the peripheral olfactory organ from a representative of the large and economically important order of teleost fishes, the Perciformes, shows a compact structure with olfactory sensory neurons distributed widely throughout the olfactory chamber. The spatial organization of the nasal cavity in the bottom-dwelling round goby (Gobiidae, Neogobius melanostomus) was ...

Like many other species of petrel, blue petrel (Halobaena caerulea) are able to return to their nest burrows at night in complete darkness. Since petrels have a well-developed olfactory system, we carried out an experiment to test whether blue petrels use olfaction to localise their nest burrows. Incubating birds were injected intranasally with a zinc sulphate solution, which reversibly impairs...