The principle of antisense oligonucleotide (AS-OD) technologies is based on the specific inhibition of unwanted gene expression by blocking mRNA activity. It has long appeared to be an ideal strategy to leverage new genomic knowledge for drug discovery and development. In recent years, AS-OD technologies have been widely used as potent and promising tools for this purpose. There is a rapid incr...

Let [Formula: see text] be an alternating group of degree n. We know that [Formula: see text] is 2-fold OD-characterizable and [Formula: see text] is 6-fold OD-characterizable. In this note, we first show that [Formula: see text] and [Formula: see text] are 14-fold and 7-fold OD-characterizable, respectively, and second show that certain groups [Formula: see text] with that [Formula: see text] ...

We present a new method for optic disk (OD) detection in a retinal image. It is an hybrid approach which uses properties of both appearance and model-based approaches which are mostly used for OD detection. An extrema pyramidal decomposition is employed and hill type topographical features are extracted at the lowest level of the image pyramid. The detected hill points are characterised as cand...

Ocular dominance (OD) plasticity in the mouse primary visual cortex (V1) declines during aging and is absent beyond postnatal day (P) 110 when mice are raised in standard cages (SCs; Lehmann and Löwel, 2008). In contrast, raising mice in an enriched environment (EE) preserved a juvenile-like OD plasticity into late adulthood (Greifzu et al., 2014). EE raising provides the mice with more social ...

The health, growth and development of a cohort of children (n = 59) aged 6 months to 4 years and born after oocyte donation (OD) was compared with that from a group of children born after in-vitro fertilization (IVF) (n = 126). The study was performed by questionnaire, and the response rate was 100% in the OD group and 95% in the IVF group. All OD children were healthy. Three IVF children had a...

Recently, we developed an immunoglobulin G (IgG)-capture BED-enzyme immunoassay (BED-CEIA) to identify recent human immunodeficiency virus (HIV) type 1 (HIV-1) seroconversion for use in incidence estimates. We have established an algorithm for its use; developed quality control reagents to monitor the assay; and evaluated its performance for interrun, intrarun, and operator variability. Analysi...

BACKGROUND Aclidinium bromide is a new long-acting muscarinic antagonist (LAMA) indicated for maintenance bronchodilator treatment of chronic obstructive pulmonary disease (COPD). The efficacy of aclidinium was compared with tiotropium and glycopyrronium, using a network meta-analysis (NMA) of randomized controlled trials (RCTs) in moderate-to-severe COPD patients. METHODS A systematic review...

OBJECTIVES To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. DESIGN A randomised, double-blind, double-dummy, parallel group, multicentre, international, phase III non-inferiority study. SETTING 54 centres in 13 countries. PATIE...

To evaluate the bioavailability of a new theophylline preparation suitable for once-a-day (od) oral administration, we performed a nonrandomized crossover study in which the absorption of the OD and a standard twice-a-day (bid) preparation were compared. Eight stable asthmatic patients, after having achieved steady-state, received an average of 975 mg of OD preparation at 8 PM. The protocol was...

Locating the Optic Disc (OD) is of critical importance in a retinal analysis system. This paper presents a fast algorithm for the automatic localization of OD in digital fundus retinal images. OD localization follows the Blood Vessel Detection (BVD). A morphology based approach is proposed for BVD. OD is localized by exploiting the property that it is a bright region and the density of blood ve...