The article “efficacy of hepatitis B vaccine in those who lost hepatitis B surface antigen during follow-up” published recently in Hepatitis Monthly (1), described the efficacy of HBV vaccine in chronic HBV patients who had been found negative for HBsAg and HBV DNA in sera. The manuscript was highlighted by an Editorial in the same issue (2). The manuscript dealt with a group of chronic HBV pat...

Occult hepatitis B infection (OBI) is still a topic of debate worldwide. It defined as the presence virus (HBV) DNA in serum and/or liver from HBsAg-negative subjects. OBI may lead to development cirrhosis and hepatocellular carcinoma. continues present several unique challenges organ transplantation despite availability an effective vaccine prevent HBV introduction oral therapy treat infection...

conclusions based on our results, it seems that there were no cases of obi among chronic hcv-infected patients with thalassemia and bleeding disorders, particularly hemophilia. however, to improve decisions concerning obi screening, especially in transfusion centers, and concerning the use of comprehensive screening methods, more original studies with more precise laboratory techniques and larg...