background: the aim was to investigate the relationships among lean mass (lm), fat mass (fm), and bone mineral density (bmd) in women stratified by body mass index (bmi) (bmi – normal-weight, overweight, obese) and to determine threshold at which body fat assumes negative relationship with bmd. methods: this was a cross-sectional study in 471 healthy caucasian women, aged 18-67 years. bmd, lm, ...

Introduction: The effective method of treatment of Polycystic Overy Syndrome (PCOS) is lifestyle modification. The aim of this study was to evaluate the effect of 12 weeks aerobic exercise on DHEAso4, 17OH-Progestron Concentrations, number of follicles and menstrual condition of women with PCOS. Methods: In this clinical trial, 40 PCOS patients lean (BMI<20) and obese (BMI>25) randomly divided ...

This study aimed to elucidate possible age-related changes in islet blood perfusion in lean and obese C57BL/6 mice. Obese mice aged 1 mo were hyperglycemic and hyperinsulinemic and had an increased islet blood flow compared with age-matched lean mice. This augmented blood flow could be abolished by pretreatment with leptin. The islet blood perfusion was, in contrast to this, markedly decreased ...

Leptin deficiency causes obesity in rodents and humans, but circulating levels of leptin are paradoxically elevated in obesity. The mechanisms underlying this leptin resistance are unknown, but may involve reduced leptin transport across the blood-brain barrier via short isoforms of the leptin receptor (Ob-R). Here, we first quantified short Ob-R mRNA expression in isolated rat cerebral microve...

Viable mice homozygous for two recessive autosomal genes, hairless (hr) and obese (ob) were produced with an average life span of 538 +/- 34.1 days. On the average, hairless-obese mice weighed about 73 percent as much as obese mice. Since obese mice consumed approximately 73 percent as much oxygen per gram body weight per hour as hairless-obese mice at about 24 degree C, the weight averages app...

Some individuals of the mixed group of "lean" littermates (+/ ob and +/+) of (C57BL/6J ob/ob) often suggest phenotypic characteristics of ob/ob animals. Therefore, it was of interest to determine whether expression of the ob gene had physiological significance in +/ ob animals. Body weight (BW), fasting blood glucose (FBG), and body core temperature (Tr) were monitored between 62 and 364 days o...

background: physical activity has shown to prevent type diabetes 2. however, the type, intensity and amount of effective physi­cal activity as well as individuals' needs according to level of their risk for type 2 diabetes have not been clarified comprehen­sively. this study investigated a relation between moderate aerobic physical activity ≥150 minuets/week with de­creased risk of type 2 diabe...